LAMISIL® Novartis Pharmaceuticals Terbinafine HCl Antifungal Action And Clinical Pharmacology: Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations terbinafine is fungicidal against dermatophytes, molds and certain dimorphic fungi. The activity against yeasts is fungicidal or fungistatic, depending on the species. Terbinafine interferes specifically with fungal sterol biosynthesis by inhibition of squalene epoxidase in the fungal cell membrane. This leads to a deficiency in…
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Lamisil (Terbinafine)
(Pharmaceutical)Lactaid (Lactase)
(Pharmaceutical)LACTAID® McNeil Consumer Products Lactase Enzyme Lactose Digestant Action And Clinical Pharmacology: Converts the disaccharide lactose via hydrolysis into its monosaccharide components, glucose and galactose. Tablets: In vivo activity has been demonstrated with drug administration at time of milk consumption and at time of consumption of other lactose containing solid and liquid foods. Drops: Fifteen drops will hydrolyze nearly all of the lactose in 1 L of milk at refrigerator…
Lactrase
(Pharmaceutical)LACTRASE® Rivex Pharma Lactase Lactose Digestant Action And Clinical Pharmacology: Lactose is a nonabsorbable disaccharide found as a common constituent in most dairy products. Under normal conditions, dietary lactose is hydrolyzed in the jejunum and proximal ileum by beta-D-galactosidase or lactase. Lactase is produced in the brush border of the columnar epithelial cells of the intestinal villi. Lactase hydrolyzes lactose into 2 monosaccharides, glucose and galactose, that are readily absorbed…
JE
(Pharmaceutical)JE-VAX® Connaught Japanese Encephalitis Virus Vaccine Inactivated Active Immunizing Agent Action And Clinical Pharmacology: Japanese encephalitis (JE), a mosquito-borne arboviral Flavivirus infection is the leading cause of viral encephalitis in Asia. Infection leads to overt encephalitis in only 1 of 20 to 1 000 cases. Encephalitis usually is severe, resulting in a fatal outcome in 25% of cases and residual neuropsychiatric sequelae in 50% of cases. JE acquired during the…
Ipecac Syrup
(Pharmaceutical)IPECAC SYRUP General Monograph, Emetic Pharmacology: Ipecac induces vomiting by both gastric irritation and central stimulation of the chemoreceptor trigger zone. Approximately 95% of patients vomit within 15 to 30 minutes of administration of a therapeutic dose and vomiting usually persists for 30 minutes to 2 hours. Approximately 28 to 60% of an ingested toxin will be removed by emesis if ipecac is given within 5 minutes following ingestion of…
Invirase (Saquinavir Mesylate)
(Pharmaceutical)INVIRASE Roche Saquinavir Mesylate HIV Protease Inhibitor – Antiretroviral Agent Action And Clinical Pharmacology: Saquinavir is a selective inhibitor of the viral pol-encoded aspartic protease which cleaves precursor molecules into the structural proteins of the mature virion core and activates reverse transcriptase during the HIV growth cycle. Because of these functions, this protease is essential for the release of infectious virus (as proved by active site mutagenesis). Saquinavir is a…
Inhibace (Cilazapril)
(Pharmaceutical)INHIBACE® Roche Cilazapril Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Cilazapril is an angiotensin converting enzyme (ACE) inhibitor, which is used in the treatment of hypertension and congestive heart failure. Cilazapril suppresses the renin-angiotensin-aldosterone system and thereby reduces both supine and standing systolic and diastolic blood pressures. Renin is an enzyme that is released by the kidneys into the circulation to stimulate the production of angiotensin I, an inactive…
ImmuCyst (Bacillus Calmette-Guerin)
(Pharmaceutical)ImmuCyst® Connaught Bacillus Calmette-Guerin (BCG), substrain Connaught Antineoplastic Action And Clinical Pharmacology: When administered intravesically as a cancer therapy, BCG promotes a local acute inflammatory and sub-acute granulomatous reaction with histiocytic and leukocytic infiltration in the urothelium and lamina propria of the urinary bladder. The local inflammatory effects are associated with an elimination or reduction of superficial cancerous lesions of the urinary bladder. The antitumor effect appears to be T-lymphocyte-dependent….
Imitrex (Sumatriptan Succinate)
(Pharmaceutical)IMITREX® Injection/Tablets IMITREX® Nasal Spray Glaxo Wellcome Sumatriptan Succinate Sumatriptan Migraine Therapy Action And Clinical Pharmacology: Sumatriptan has been shown to be effective in relieving migraine headache. It is an agonist for a vascular 5-hydroxytryptamine1D (5-HT1D) receptor subtype (a member of the 5-HT1 family), and has only weak affinity for 5-HT1A receptors and no significant activity (as measured using standard radioligand binding assays) or pharmacological activity at 5-HT2, 5-HT3, 5-HT4,…
Immunine VH
(Pharmaceutical)IMMUNINE® VH Baxter Factor IX Concentrate (Human) Blood Coagulation Factor Action And Clinical Pharmacology: Coagulation factor IX is one of the clotting factors found in normal human blood and is required for normal clot formation. I.V. administration of Immunine VH, factor IX concentrate (human) vapor heated, Immuno provides an increase in plasma levels of factor IX and can temporarily correct the coagulation defect of patients with factor IX deficiency. The…