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MIGRANAL® Novartis Pharmaceuticals Dihydroergotamine Mesylate Migraine Therapy Action And Clinical Pharmacology: Dihydroergotamine displays agonist activity at the 5-HT1D receptor, which, by reducing 5-HT neuronal function and/or contracting elements of the cranial vasculature and/or suppressing neurogenic inflammation, is believed to underlie its antimigraine efficacy. It also displays affinity for the 5-HT1C receptor and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine displays blocking actions at alpha adrenoreceptors, with a direct stimulating effect…

MIN-OVRAL® 21 MIN-OVRAL® 28 Wyeth-Ayerst Levonorgestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Although the primary mechanism of action is inhibition of ovulation, the effectiveness of Min-Ovral may also result from other mechanisms of action, such as hostility of the cervical mucus to sperm penetration and migration. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or…

MIDAMOR® MSD Amiloride HCl Antikaliuretic – Diuretic Action And Clinical Pharmacology: Amiloride is an antikaliuretic drug with mild natriuretic diuretic and antihypertensive activity. The activities may be additive to the effects of thiazides or other saluretic-diuretic agents. The principal use is to conserve potassium in selected patients receiving kaliuretic-diuretic agents. Amiloride interferes with the mechanism involved in the exchange of sodium for potassium in the distal convoluted tubule and collecting…

MICRONOR® Janssen-Ortho Norethindrone Oral Contraceptive Action And Clinical Pharmacology: The mechanism of contraception action of Micronor tablets is multicausal, primarily at the local pelvic level and secondarily at the systemic level. The hormonal effect is mainly progestational. Pelvic effects include changes in the cervical mucus and endometrium. Systemic effects involve mainly the inhibition of secretion of pituitary gonadotropins which in turn prevents follicular maturation and ovulation. Studies by Moghissi, Beck,…

MEXITIL® Boehringer Ingelheim Mexiletine HCl Antiarrhythmic Action And Clinical Pharmacology: Mexiletine is a class 1B antiarrhythmic agent based on the classification system of Vaughan-Williams with local anesthetic properties, similar in structure and activity to lidocaine. Mexiletine blocks the fast sodium channel in cardiac tissues, especially the Purkinje network, without involvement of the autonomic system. Mexiletine reduces the rate of rise and amplitude of the action potential and decreases automaticity (increases…

MICANOL® Canderm Pharma Anthralin Psoriasis Treatment Action And Clinical Pharmacology: Micanol cream provides the action of anthralin in a pharmaceutically elegant base formulated to minimize staining and irritation. With successful treatment, scales will be removed and the lesions will flatten. The lesions will take time to blanch after flattening has occurred. Indications And Clinical Uses: For the treatment of psoriasis. Contra-Indications: Do not use on areas of skin where inflammation…

MICOZOLE Taro Miconazole Nitrate Antifungal Indications And Clinical Uses: For the local treatment of vulvovaginal candidiasis (moniliasis) and has been shown to be effective in both pregnant and nonpregnant women and in women taking oral contraceptives. Miconazole, a synthetic imidazole derivative, exhibits a broad spectrum of antimicrobial activity for the use in the systemic treatment and local treatment of vaginal and topical fungal infections. It is particularly active against Candida…

MICATIN® McNeil Consumer Products Miconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Miconazole exhibits broad spectrum in vitro fungistatic activity; e.g., against species of the genus Candida. Studies with C. albicans indicate that at low concentrations, miconazole acts primarily on the yeast cell membrane resulting in selective inhibition of the uptake of precursors of RNA and DNA (purines) and mucopolysaccharide (glutamine). In addition, in vitro antibacterial activity has been reported…

METRETON® Schering Prednisone Acetate – Chlorpheniramine Maleate – Ascorbic Acid Glucocorticoid – Antihistamine Action And Clinical Pharmacology: Metreton combines the anti-inflammatory and antiallergic effects of the corticosteroid prednisone with the antihistaminic activity of chlorpheniramine. In addition, Metreton tablets contain ascorbic acid. By using prednisone and chlorpheniramine in combination, comparable results usually are obtained with smaller amounts of corticosteroid than when the corticosteroid is given alone. Indications And Clinical Uses: For…

METROCREAM™ METROGEL® Galderma Metronidazole Antirosacea Agent Action And Clinical Pharmacology: Metronidazole topical preparations are particularly effective against the inflammatory, papulopustular component of rosacea. The mechanisms by which topical metronidazole acts in reducing inflammatory lesions of rosacea are unknown, but may include an anti-bacterial and/or an anti-inflammatory effect. Pharmacokinetics: Metronidazole is rapidly and nearly totally absorbed after oral administration. The drug is not significantly bound to serum proteins and distributes well…