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MIREZE® Allergan Nedocromil Sodium Antiallergic – Anti-inflammatory Action And Clinical Pharmacology: Nedocromil displays specific antiallergic and anti-inflammatory properties. The pharmacological actions of nedocromil in many respects resemble those of sodium cromoglycate, a compound which has been shown to have effects on both the symptoms of ocular allergic inflammation and the level of inflammatory mediators present in the tears. Nedocromil is not only an inhibitor of the immunological release of inflammatory…

MIRAPEX® Boehringer Ingelheim Pramipexole Dihydrochloride Antiparkinsonian Agent – Dopamine Agonist Action And Clinical Pharmacology: Pramipexole is a non ergot dopamine agonist with high in vitro specificity at the D2 subfamily of dopamine receptors. Pramipexole is a full agonist and exhibits higher affinity to the D3 receptor subtypes (which are in prominent distribution within the mesolimbic area) than to D2 or D4 receptor subtypes. While pramipexole exhibits high affinity for the…

MITOMYCIN FOR INJECTION USP Novopharm Antineoplastic Action And Clinical Pharmacology: Mitomycin was first investigated as an antibiotic in Japan. It was then found to be active as an antineoplastic agent. It selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The exact point of mitomycin attachment to DNA remains unknown. There is a correlation between the guanine and cytosine content of DNA and the degree of mitomycin-induced cross-linking. At high concentrations…

MIVACRON® Glaxo Wellcome Mivacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Mivacurium is a short-acting, nondepolarizing skeletal neuromuscular blocking agent which is hydrolyzed by plasma cholinesterase. Mivacurium results in a blockade of neuromuscular transmission by binding competitively with cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine. Pharmacodynamics: The time to maximum neuromuscular block is similar for mivacurium and intermediate-acting agents (e.g., atracurium), but…

MINIPRESS™ Pfizer Prazosin HCl Antihypertensive Action And Clinical Pharmacology: Prazosin causes a decrease in total peripheral resistance. Animal studies suggest that the vasodilator effect of prazosin is related to selective blockade of post-synaptic alpha1-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect is confined mainly to the level of the resistance vessels (arterioles). Hemodynamic studies have been carried out in man following acute single dose administration…

MINESTRIN™ 1/20 Parke-Davis Norethindrone Acetate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Minestrin 1/20 achieves its contraceptive effect primarily by inhibition of ovulation through gonadotrophin suppression. It is well-established that oral contraceptives containing estrogen and progestogen affect hypothalamic, pituitary and ovarian functions. They may alter many other physiological systems. Although the exact mechanisms of action are incompletely understood, there is universal agreement that the inhibition of the ovulatory…

MINITRAN™ 3M Pharmaceuticals Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance…

Introduction Minocin is a tetracycline antibiotic used to treat various bacterial infections, such as urinary tract infections, severe acne, tick fever, chlamydia, gonorrhea, etc. Action And Clinical Pharmacology Minocycline is a tetracycline with antibacterial activity against some Gram-negative and Gram-positive organisms. The action is primarily bacteriostatic and it is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Indications And Clinical Uses Infections due to susceptible strains…

MINTEZOL® MSD Thiabendazole Anthelmintic Action And Clinical Pharmacology: Thiabendazole is an anthelmintic for the treatment of various nematode infections of man. Thiabendazole provides systemic treatment for cutaneous larva migrans. It causes worms to be eliminated spontaneously from the cutaneous blister or it eases their manual removal. In some instances the devitalized worm is not expelled and encystment with lysis occurs. In some patients, the drug has been useful in the…

MIOCHOL®-E CIBA Vision Acetylcholine Chloride – Electrolytes Miotic Action And Clinical Pharmacology: Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by hydrolysis to acetic acid and choline. Direct application of acetylcholine to the iris will cause rapid miosis of short duration. Topical ocular instillation…