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MONITAN® Wyeth-Ayerst Acebutolol HCl Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Acebutolol is a beta-adrenergic receptor blocking agent. In vitro and in vivo animal studies have shown that it has a preferential effect on beta1-adrenoreceptors, chiefly located in cardiac muscle. This preferential effect is not absolute, however, and at higher doses acebutolol also inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. It possesses some partial agonist activity…

MONOPRIL™ Bristol-Myers Squibb Fosinopril Sodium Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Fosinopril is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of mild to moderate essential hypertension and in the management of symptomatic congestive heart failure. Following oral administration, fosinopril is rapidly hydrolyzed to fosinoprilat, its principal active metabolite. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor…

MODULON® Axcan Pharma Trimebutine Maleate Lower Gastrointestinal Tract Motility Regulator Action And Clinical Pharmacology: Trimebutine is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has a marked antiserotonin activity especially on “mu” receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig taenia coli and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity….

MODURET® MSD Hydrochlorothiazide – Amiloride HCl Diuretic – Antihypertensive Action And Clinical Pharmacology: Moduret is a diuretic/antihypertensive combining the potent natriuretic action of hydrochlorothiazide with the potassium conserving property of amiloride. The mild diuretic and antihypertensive actions of amiloride are additive to the natriuretic, diuretic and antihypertensive activity of the thiazide while minimizing the loss of potassium and lessening the likelihood of acid base imbalance. The onset of the diuretic…

MOGADON® Roche Nitrazepam Hypnotic – Anticonvulsant Action And Clinical Pharmacology: Nitrazepam is a benzodiazepine with hypnotic and anticonvulsant properties. In sleep laboratory studies, nitrazepam decreased sleep latency, increased total sleep time and decreased awake time. There is delay in the onset, and decrease in the duration of REM sleep. Nitrazepam is reported to significantly decrease stage 1, 3 and 4 sleep and to increase stage 2. Following discontinuation of the…

MOISTUREL® Westwood-Squibb Petrolatum – Dimethicone Emollient – Moisturizer Indications And Clinical Uses: Heals and protects dry sensitive skin. Relieves associated itching. Contra-Indications: The presence of acute inflammation or a known sensitivity to any of its components. Dosage: Apply to skin as often as needed, preferably after bathing, to soften and smooth dry skin and relieve itching. Availability And Storage: Cream: Each jar contains: petrolatum 30% and dimethicone 1% in a…

MODECATE® MODECATE® CONCENTRATE Squibb Fluphenazine Decanoate Antipsychotic Action And Clinical Pharmacology: The effects of fluphenazine decanoate are the same as those of fluphenazine HCl; however, the slow release of the decanoate derivative of fluphenazine from the site of injection results in a prolonged duration of action. Once released in the blood, fluphenazine decanoate is rapidly hydrolyzed by blood esterases with no attenuation of its antipsychotic action. The onset of action…

MOBIFLEX® Roche Tenoxicam Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Tenoxicam is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action, as with other nonsteroidal anti-inflammatory agents, is not yet completely known. Tenoxicam is an inhibitor of prostaglandin biosynthesis both in vitro and in vivo (protects mice against arachidonic acid induced toxicity). In vitro tests of leukocyte peroxidase also suggest that tenoxicam may act as a…

MODITEN® HCl Squibb Fluphenazine HCl Antipsychotic Action And Clinical Pharmacology: Fluphenazine hydrochloride exerts activity at various levels of the CNS as well as on peripheral organ systems, which accounts for its antipsychotic action and side effects. Indirect evidence indicates that the antipsychotic effects of phenothiazines are linked to their effect in blocking dopamine and other catecholamine receptor sites. Fluphenazine has less potentiating effect on CNS depressants and anesthetics and appears…

MODITEN® ENANTHATE Squibb Fluphenazine Enanthate Antipsychotic Action And Clinical Pharmacology: The esterification of fluphenazine markedly prolongs its duration of effect without unduly attenuating its beneficial action. The onset of action generally appears 24 to 72 hours after injection, and the antipsychotic effects become significant within 48 to 96 hours. Amelioration of symptoms continues for 1 to 3 weeks or longer, with an average duration of effect of about 2 weeks….