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MUCOMYST® Roberts Acetylcysteine Mucolytic – Antidote for Acetaminophen Poisoning Action And Clinical Pharmacology: The viscosity of pulmonary mucous secretions depends on the concentrations of mucoprotein and to a lesser extent deoxyribonucleic acid (DNA). The latter increases with increasing purulence owing to cellular debris. The mucolytic action of acetylcysteine is related to the sulfhydryl group in the molecule. This group probably “opens” disulfide linkages in mucus thereby lowering the viscosity. The…

MOTRIN® IB McNeil Consumer Products Ibuprofen Analgesic – Antipyretic – Anti-inflammatory Action And Clinical Pharmacology: Ibuprofen is a member of the class of agents commonly known as nonsteroidal anti-inflammatory drugs (NSAIDs). Consistent with this classification, ibuprofen exhibits anti-inflammatory activity at higher dosage ranges. At lower adult single doses relevant to a 200 mg dosage strength (200 to 400 mg) ibuprofen relieves pain of mild to moderate intensity and reduces fever….

MOTRIN® Pharmacia & Upjohn Ibuprofen Anti-inflammatory – Analgesic – Antipyretic Action And Clinical Pharmacology: Ibuprofen has demonstrated anti-inflammatory, analgesic and antipyretic activity in animal studies designed to specifically demonstrate these effects. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not completely understood, but may be related to prostaglandin synthetase inhibition. Ibuprofen does not alter the course of the underlying disease. Ibuprofen has no demonstrable glucocorticoid effect….

MS•IR® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the…

MS CONTIN® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

MORPHINE SULFATE INJECTION BP (1 mg/mL and 2 mg/mL) Faulding Opioid Analgesic Action And Clinical Pharmacology: Morphine exerts its main actions by acting as an agonist at specific receptor sites in the CNS. Morphine produces many effects including analgesia, decreased gastrointestinal motility, respiratory depression, nausea, vomiting, drowsiness, changes in mood and alterations of the endocrine and autonomic nervous systems. Maximum analgesia occurs within 50 to 90 minutes after s.c. administration,…

MoRu-Viraten BERNA™ Berna Products Measles and Rubella Virus Vaccine, Live, Attenuated Active Immunizing Agent Action And Clinical Pharmacology: MoRu-Viraten Berna is a live virus vaccine for immunization against measles (rubeola) and rubella (German measles). A single dose of MoRu-Viraten Berna vaccine was administered to 26 children, 15 months to 9 years of age, who were seronegative [a rubella hemagglutination-inhibition (HI) titer of 256). The viral vaccine strains that comprise MoRu-Viraten…

MOTILIUM® Janssen-Ortho Domperidone Maleate Upper Gastrointestinal Motility Modifier Action And Clinical Pharmacology: Domperidone is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties. Domperidone effectively increases esophageal peristalsis and lower esophageal sphincter pressure (LESP), increases gastric motility and peristalsis, enhances gastroduodenal coordination and consequently facilitates gastric emptying and decreases small bowel transit time. The mechanism of action of domperidone is related to its peripheral dopamine…

Motrin (Children’s) McNeil Consumer Products Ibuprofen Analgesic – Antipyretic Action And Clinical Pharmacology: Ibuprofen is a member of the class of agents commonly known as nonsteroidal anti-inflammatory drugs (NSAIDs). Consistent with this classification, ibuprofen exhibits anti-inflammatory activity at higher dosage ranges. At lower adult single doses (200 to 400 mg) relevant to the nonprescription analgesic/antipyretic indications and dosage strength, ibuprofen relieves pain of mild to moderate intensity and reduces fever….

MONISTAT® 7 Cream MONISTAT 7 Vaginal Suppositories MONISTAT® 7 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® DERM Cream MONISTAT® 3 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® 3 Vaginal Ovules McNeil Consumer Products Miconazole Nitrate Antifungal Action And Clinical Pharmacology: Depending upon concentration, miconazole exhibits broad spectrum in vitro fungistatic or fungicidal activity against species of the genus Candida. Miconazole also inhibits several other genera of fungi, including…