You searched for : 'K'

PULMOZYME™ Roche Dornase Alfa Recombinant Enzyme that Cleaves DNA Action And Clinical Pharmacology: Dornase alfa for inhalation is a sterile, clear, colorless, highly purified solution of recombinant human deoxyribonuclease 1 (rhDNase), an enzyme which selectively cleaves DNA. The protein is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing DNA encoding for the native human protein, deoxyribonuclease 1 (Dnase). The product is purified by tangential flow filtration and column…

PUREGON™ Organon Follitropin Beta Gonadotropin Action And Clinical Pharmacology: Puregon is a freeze-dried preparation containing highly purified human follicle stimulating hormone (hFSH) prepared by recombinant DNA technology. The active substance, follitropin beta, is a heterodimeric glycoprotein with a molecular mass of approximately 35-45kD. It is produced by a Chinese hamster ovary (CHO) cell line transfected with a plasmid containing two subunit genes encoding human FSH. Structural analysis has shown that…

PROTROPIN® Roche Somatrem Growth Hormone Action And Clinical Pharmacology: Somatrem is a polypeptide (methionyl human growth hormone) produced by recombinant DNA technology using the gene for human growth hormone. Somatrem has the same amino acid sequence as pituitary-derived human growth hormone plus an additional amino acid, methionine, on the N-terminus of the molecule. The two molecules also have the same disulfide bond arrangement and the same secondary and tertiary structure….

PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestin Action And Clinical Pharmacology: Medroxyprogesterone, an orally active progestational steroid (progestin) derived from a natural source (soy beans), when administered to women with adequate levels of estrogen (endogenous or exogenous), transforms a proliferative endometrium into a secretory endometrium. Furthermore, the anticancer activity of medroxyprogesterone at pharmacologic doses, may be dependent on its effect on the hypothalamic/pituitary/gonadal axis, estrogen receptors and metabolism of steroids…

PROVIODINE® Rougier Povidone-Iodine Antiseptic Action And Clinical Pharmacology: Proviodine is iodine complexed with povidone (polyvinyl-pyrrolidone). The compound is soluble in water forming a golden brown solution. Like iodine, the solution of the iodine complex is bactericidal and fungicidal. However, unlike solutions of iodine, it is non-staining. The antiseptic action of povidone-iodine solutions is due to the available iodine present in the complex. Indications And Clinical Uses: Derma: Useful as a…

PROZAC® Lilly Fluoxetine HCl Antidepressant – Antiobsessional – Antibulimic Action And Clinical Pharmacology: The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to selectively inhibit the neuronal reuptake of serotonin. At clinically relevant doses fluoxetine blocks the uptake of serotonin into human platelets. Antagonism of muscarinic, histaminergic and a1-adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative and cardiovascular effects…

PROSTIN® E2 Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Orally administered dinoprostone stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions observed in the term uterus during spontaneous labor. Whether or not this action results from a direct or indirect effect of dinoprostone on the myometrium has not been determined with certainty. Dinoprostone’s ability to stimulate gastrointestinal tract smooth…

PROSTIN® VR Pharmacia & Upjohn Alprostadil Prostaglandin Action And Clinical Pharmacology: Alprostadil (also known as prostaglandin E1) relaxes the ductus arteriosus in early postnatal life and supports its patency when continuously infused i.v. or intra-arterially in neonates with congenital heart defects who depend on a patent ductus for survival. The desired pharmacological effects are obtained with an initial dosage of 0.1 µg/kg/minute. Higher doses do not offer added benefit. Postnatally…

PROSTIN® E2 Vaginal Gel Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Dinoprostone is a synthetic analogue of Prostaglandin E2 (PGE2). The major clinical application of PGE2 relates to its effect on uterine smooth muscle. This property has led to its obstetrical use for term labor induction and preterm evacuation of uterine contents (for fetal death in utero, hydatidiform mole and abortion). Similarly, this effect on other smooth muscle…

PROTAMINE SULFATE INJECTION Pharmaceutical Partners Heparin Antagonist Action And Clinical Pharmacology: When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed which results in the loss of anticoagulant activity of both drugs. Protamine has a rapid onset of action. Neutralization of heparin occurs within 5 minutes after i.v. administration. Although the metabolic fate…