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PACIS™ Faulding Bacillus Calmette-Guerin (BCG), substrain Montreal Antineoplastic Action And Clinical Pharmacology: PACIS (Bacillus Calmette-Guerin (BCG), substrain Montreal) promotes a local inflammatory reaction with histiocytic and leukocytic infiltration in the urinary bladder. The local inflammatory effects are associated with an apparent elimination or reduction of superficial cancerous lesions of the urinary bladder. The exact mechanism by which this is accomplished is unknown. Indications And Clinical Uses: For intravesical use in…

PYRIDIUM® Parke-Davis Phenazopyridine HCl Urinary Analgesic Action And Clinical Pharmacology: Phenazopyridine is excreted in the urine where it exerts a topical analgesic effect on the mucosa of the urinary tract. This action helps to relieve pain, burning, urgency and frequency. The precise mechanism of action is unknown. Pharmacokinetics: The pharmacokinetic properties of phenazopyridine have not been determined. Phenazopyridine and its metabolites are rapidly excreted by the kidneys. In a small…

PALAFER® CF SmithKline Beecham Ferrous Fumarate Compound Prenatal Supplement Indications And Clinical Uses: For the treatment of hypochromic anemia and avitaminosis C and to prevent megaloblastic anemia of pregnancy due to folic acid depletion. Contra-Indications: Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of hemolytic anemias unless an iron-deficient state also exists, since storage of iron with a possible exogenous hemosiderosis can result. Precautions: Where anemia exists, its…

PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PURIFIED PROTEIN DERIVATIVE Connaught PPD-B (Mantoux) Diagnostic Antigen Indications And Clinical Uses: If there is reason to believe that an individual is infected with a mycobacterium other than M. tuberculosis var. hominis, as an added diagnostic procedure, PPD-B (Mantoux), 0.05 g per test dose may be injected using Tuberculin PPD (Mantoux), 5 TU (bioequivalent) per test dose, as a control. Injections are usually made in the same forearm not less…

PURINETHOL® Glaxo Wellcome Mercaptopurine Antileukemic Action And Clinical Pharmacology: Clinical studies have shown the absorption of an oral dose of mercaptopurine in man is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown. I.V. administration of an investigational preparation of mercaptopurine revealed a plasma half-disappearance time of 21 minutes in children and 47 minutes in adults. The volume of distribution usually exceeded that…

PYRIBENZAMINE® Novartis Consumer Health Tripelennamine HCl Antihistamine Indications And Clinical Uses: Seasonal or nonseasonal allergic reactions. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or…

gasPYLORID® Glaxo Wellcome Ranitidine Bismuth Citrate Histamine H2-receptor Antagonist with H. pylori Suppressive Activity Note: For additional safety information on clarithromycin and ranitidine, consult the individual product monographs. Action And Clinical Pharmacology: Ranitidine bismuth citrate is a complex of ranitidine, a histamine H2-receptor antagonist, and bismuth citrate, which together produce H. pylori suppressive activity. Following ingestion, ranitidine bismuth citrate dissociates in intragastric fluid, giving rise to ranitidine, and soluble and…

PULMICORT® NEBUAMP® Astra Budesonide Glucocorticosteroid – Asthma Therapy Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The late…

PULMICORT® TURBUHALER® Astra Budesonide Glucocorticosteroid for the Treatment of Bronchial Asthma Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short…