Proviodine (Povidone-Iodine)





Action And Clinical Pharmacology: Proviodine is iodine complexed with povidone (polyvinyl-pyrrolidone). The compound is soluble in water forming a golden brown solution. Like iodine, the solution of the iodine complex is bactericidal and fungicidal. However, unlike solutions of iodine, it is non-staining. The antiseptic action of povidone-iodine solutions is due to the available iodine present in the complex.

Indications And Clinical Uses: Derma: Useful as a topical antimicrobial in preventing infections in lacerations, minor cuts, abrasions and burns caused by iodine susceptible pathogenic organisms. Helps prevent acute and chronic inflammatory infections such as in acne vulgaris. In pyodermas, as a topical adjunct to systemic antimicrobial therapy.

Detergent: Pre and postoperative scrubbing or washing. General antiseptic use.

Douche: For nonspecific vaginitis, vaginitis and vulvovaginitis associated with Trichomonas vaginalis and monilial infection. Routine cleansing douche and deodorant. Adjunctive use in preoperative vaginal prepping.

Hydro: Not intended for topical application but may be used as an additional antiseptic measure for hydrotherapy baths.

Ointment: First aid antisepsis in abrasions, cuts, minor burns, bacterial or mycotic dermatoses. The treatment of infected wounds and lacerations.

Ovules: For nonspecific vaginitis, vaginitis and vulvovaginitis associated with Trichomonas vaginalis and monilial infection.

Solution: Pre and postoperative skin and mucous membrane antisepsis. For disinfection and prevention of infection in abrasions, cuts, burns and wounds. For oral infections (stomatitis, etc.) and dental procedures.

Vaginal Gel: For nonspecific vaginitis, vaginitis and vulvovaginitis associated with Trichomonas vaginalis and monilial infection.

Precautions: Use with caution in patients known to be allergic to iodine. If irritation, redness or swelling develops, discontinue use of the product and institute appropriate measures. Blue stains on starched linen will wash off with soap and water.

Lactation: Povidone-iodine as vaginal douche may produce elevated breast milk iodine levels.

Adverse Reactions: Although rare, local hypersensitivity reactions have occurred. Serum PBI may increase temporarily in some patients after topical application of povidone-iodine.

Dosage And Administration: Derma: Wet affected skin areas. Apply a sufficient amount of Proviodine Derma and work up rich lather. Allow lather 2 to 3 minutes contact with the affected areas. Rinse thoroughly. Does not stain skin or natural fabrics.

Detergent: Use about 5 mL on wet hands. Carefully follow steps and techniques of thorough antiseptic cleansing, scrubbing, brushing and rinsing, as usually followed prior to surgery.

Preoperative preparation of the patient: Apply approximately 1 mL/50 cmof surface on previously shaved, wet skin. Rub thoroughly. Clean with sterile gauze soaked with water. For additional antiseptic protection, paint operating site with undiluted Proviodine Solution. Allow to dry for a few minutes.

Douche: Therapeutic douche: 2 capfuls (30 mL) diluted in 1.14 L of lukewarm water once daily for 6 to 12 days. Hygienic douche: 1 capful diluted in 1.14 L of lukewarm water, 1 to 2 times per week. Also for sitz baths. Dilutions: Generally between 5 to 10% in vol. (60 to 115 mL/1.14 L water).

Hydro: Dilute according to additional disinfection required or to individual patient need. Hydrotherapy: In general, effective concentration is 4 p.p.m. (30 mL/68.1 L water) or more. In certain cases, a higher concentration may be required.

Ointment: Apply locally 1 to 3 times per day. Cover with gauze or bandage if required.

Ovules: Insert 1 ovule high into the vagina preferably at bedtime. The use of the applicator is optional. Treatment is usually for 20 consecutive days and must be continued even during menstruation. Repeat treatment if necessary.

Solution: Preoperative preparations: swab or wet soak on operating site for 15 minutes following usual technique. Avoid pooling of the product beneath the patient. General use: swab with the nondiluted solution. Mouthwash: dilute in 1 or 2 parts of water.

Vaginal Gel: (Treatment for 12 days or more.) Insert syringe well into vagina and empty contents with plunger. Use once daily at bedtime. A vaginal douche with Proviodine Douche (dilute 30 mL/1.14 L of lukewarm water) is advisable every morning during treatment with Gel. Treatment may be continued through the menstrual cycle and during menstruation if required. If severe or prolonged irritation occurs, cease treatment.

Availability And Storage: Derma: Each mL of sudsing, antiseptic liquid cleanser contains: povidone-iodine 7.5% (0.75% available iodine). Plastic bottles of 200 mL.

Detergent: Each mL of liquid contains: povidone-iodine 7.5% (0.75% available iodine). Bottles of 115 mL, 500 mL and 5 L.

Douche: Each mL of liquid contains: povidone-iodine 10% (1% available iodine). Bottles of 200 mL with 15 mL measuring cap.

Hydro: Each mL of liquid contains: povidone-iodine 10% (1% available iodine) with no foaming agent. Plastic jugs of 5 L.

Ointment: Each g contains: povidone-iodine 100 mg (10 mg of available iodine/g). Tubes of 30 g and jars of 500 g.

Ovules: Each ovule contains: povidone-iodine 250 mg (equivalent to 25 mg available iodine), in a readily soluble and water diffusible vehicle. Boxes of 20 with applicator.

Solution: Each mL of liquid contains: povidone-iodine 10% (1% available iodine). Bottles of 115 mL, 500 mL and 5 L.

Vaginal Gel: Each 5 g applicatorful of gel contains: povidone-iodine 500 mg (equivalent to 50 mg available iodine). Tubes of 90 g with applicators.

PROVIODINE® Rougier Povidone-Iodine Antiseptic

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