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WESTCORT® Preparations Westwood-Squibb Hydrocortisone-17-valerate Topical Corticosteroid Action And Clinical Pharmacology: Studies conducted in healthy adult volunteers illustrated that 0.2% Hydrocortisone-17-valerate cream and ointment has minimal primary irritant and contact sensitization potential. Adrenal suppression studies with the cream indicated that any observed reduction in pituitary-adrenal function was rapidly reversible. Indications And Clinical Uses: Topical therapy of acute and chronic corticosteroid responsive dermatoses, where an anti-inflammatory, anti-allergenic and antipruritic activity is required…

WinRho SDF™ Cangene Rho (D) Immune Globulin (Human) Passive Immunizing Agent Action And Clinical Pharmacology: Rho (D) Immune Globulin (Human) is a sterile freeze-dried gamma globulin (IgG) fraction of human plasma containing antibodies to Rho (D), prepared by an anion-exchange column chromatography method. The incorporation of the Solvent Detergent step, which includes treatment with Tri-n-butyl phosphate and Triton X-100, in the WinRho SDF process is designed to increase the safety…

X-PREP® Purdue Frederick Standardized Sennosides Diagnostic Aid Indications And Clinical Uses: A potent cathartic to be used only for evacuation of the colon prior to contrast radiography of the gastrointestinal tract, other abdominal radiography, or examinations where a clear colon is essential for proper visualization. Also indicated prior to surgery of the colon or rectum. Contra-Indications: The “acute abdomen”. Dosage And Administration: Adults: At 10 a.m. on the day prior…

XALATAN™ Pharmacia & Upjohn Latanoprost Prostaglandin F2  Analogue Action And Clinical Pharmacology: Latanoprost, a novel prostaglandin F2  analogue, is a selective prostanoid FP receptor agonist which reduces the intraocular pressure by increasing the outflow of aqueous humor. Studies in animals and man indicate that the main mechanism of action is increased uveoscleral outflow. Primary open-angle glaucoma is a disease with characteristic optic nerve damage and a corresponding visual field defect….

WEBBER® VITAMIN E OINTMENT Novartis Consumer Health d-Alpha Tocopheryl Acetate Emollient Action And Clinical Pharmacology: Vitamin E functions as an antioxidant and stabilizer of cell membranes. Indications And Clinical Uses: For the treatment of sunburn, minor cuts and burns and other minor skin irritations. Precautions: If adverse reaction or irritation occurs, discontinue use and consult a physician. In the case of a serious burn, consult a physician. Not for ophthalmic…

WELLFERON® Glaxo Wellcome Interferon alpha-n1 (Ins) Biological Response Modifier Action And Clinical Pharmacology: Wellferon is a highly purified blend of natural human alpha interferons, obtained from human lymphoblastoid cells following induction with Sendai virus. Wellferon resembles human leukocyte interferon in that it is a mixture of natural alpha subtypes but differs in that these are present in different proportions. It also differs from recombinant alpha interferon preparations made from bacteria…

WELLBUTRIN® SR Glaxo Wellcome Bupropion HCl Antidepressant Action And Clinical Pharmacology: Bupropion is an antidepressant of the aminoketone class. It is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitors or other known antidepressant agents. Its structure closely resembles that of diethylpropion. It is related to the phenylethylamines. The mechanism of bupropion’s antidepressant activity is unknown but appears to be mediated by noradrenergic (and possibly dopaminergic), rather than serotonergic mechanisms….

VOLTAREN® Novartis Pharmaceuticals Diclofenac Sodium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. The mode of action is not fully known but it does not act through the pituitary-adrenal axis. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. This inhibitory effect may partially explain its actions. From a clinical efficacy standpoint, diclofenac sodium 75…

VUMON® PARENTERAL Bristol Teniposide Antineoplastic Action And Clinical Pharmacology: Teniposide is a semi-synthetic derivative of podophyllotoxin. In vitro, teniposide exerts a powerful cytostatic effect by first arresting cells in metaphase. Its main effect, however, is preventing cells from entering mitosis (arrest of G2 phase of cell cycle) within 1 to 2 hours after drug addition. At higher concentrations, a third effect can be observed, disintegration of part of interphase cells…

WARTEC® Pharmascience Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is a metaphase inhibitor of dividing cells. Podofilox binds to at least one binding site on tubulin. This binding prevents the tubulin polymerization required for microtubule assembly. At higher concentrations podofilox also inhibits nucleoside transport through the cell membrane. The…