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COTAZYM® Organon Pancrelipase Preparations Enzymes – Digestant Indications And Clinical Uses: Pancreatic enzyme replacement therapy in established pancreatic insufficiency where pancreatic enzymes are absent from or present in insufficient amount in the intestine: pancreatectomy, chronic pancreatitis, cystic fibrosis, steatorrhea and other malabsorption syndromes in which fat digestion is inadequate because of deficiency of pancreatic enzymes. Contra-Indications: Allergy to porcine protein. Manufacturers’ Warnings In Clinical States: In the event that capsules…

COUMADIN® DuPont Pharma Warfarin Sodium Anticoagulant Action And Clinical Pharmacology: Warfarin and other coumarin anticoagulants act by inhibiting the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. Half-lives of these clotting factors are as follows: Factor II – 60 hours, VII – 4 to 6 hours, IX – 24 hours, and X – 48 to 72…

CORTISPORIN® Glaxo Wellcome Hydrocortisone – Neomycin – Polymyxin B Compound Anti-inflammatory – Antibacterial Action And Clinical Pharmacology: Corticosteroids suppress the inflammatory response to a variety of agents and they may delay healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case. The anti-infective components in the combination are included…

CORTONE® Suspension MSD Cortisone Acetate Corticosteroid Action And Clinical Pharmacology: Cortisone is a natural product of the adrenal cortex. Cortisone is a synthetic steroid with the basic actions and effects of other glucocorticoids. Cortisone sterile suspension has a slow onset but long duration of action when compared with more soluble preparations. When daily corticosteroid therapy is required and oral therapy is not feasible, the required daily dosage may be given…

CORTONE® Tablets MSD Cortisone Acetate Corticosteroid Action And Clinical Pharmacology: Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Cortisone is a natural product of the adrenal cortex. Cortisone acetate is a synthetic steroid with the basic actions and effects of other glucocorticoids. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency…

CORTATE® 0.5 % CORTATE® 1 % Schering Hydrocortisone Topical Corticosteroid Indications And Clinical Uses: For temporary relief of minor skin irritations, itching and rashes due to eczema, dermatitis, insect bites, poison ivy, poison oak, poison sumac, soaps, detergents, cosmetics and jewellery. Manufacturers’ Warnings In Clinical States: For external use only. Do not use in or around the eyes. Do not apply to large areas of the body. Do not use…

CORTEF® Pharmacia & Upjohn Hydrocortisone Corticosteroid Action And Clinical Pharmacology: Hydrocortisone (cortisol) is a corticosteroid secreted by the adrenal cortex. In physiologic doses, it is administered to replace deficient endogenous hormones. In larger (pharmacologic) doses, hydrocortisone decreases inflammation and suppresses the immune response. It stimulates erythroid cells of the bone marrow, prolongs survival time of erythrocytes and platelets, and produces neutrophilia and eosinopenia. Hydrocortisone promotes protein catabolism, gluconeogenesis, and redistribution…

CORTIFOAM™ R & C Hydrocortisone Acetate Rectal Anti-inflammatory Action And Clinical Pharmacology: Action appears to be due to a local anti-inflammatory effect of hydrocortisone on the mucosa rather than as a result of a systemic effect. Indications And Clinical Uses: As adjunctive therapy in the treatment of ulcerative colitis of the sigmoid colon, proctosigmoiditis, granular proctitis and ulcerative proctitis. Contra-Indications: To the use of intrarectal steroids include, obstruction, abscess, perforation,…

CORTENEMA® Axcan Pharma Hydrocortisone Glucocorticoid Indications And Clinical Uses: An adjunct in the treatment of nonspecific inflammatory diseases involving the rectum, sigmoid and left colon such as idiopathic ulcerative colitis, ulcerative proctitis, regional enteritis (granulomatous colitis) with left side involvement, proctitis, proctocolitis, and radiation proctitis. Contra-Indications: Local contraindications to the use of intrarectal steroids include obstruction, abscess, perforation, peritonitis, fresh intestinal anastomoses, extensive fistulas and sinus tracts. Active tuberculosis (active,…

BURINEX® Leo Bumetanide Diuretic Action And Clinical Pharmacology: Bumetanide is a loop diuretic. The diuretic effect of bumetanide results largely from the inhibition of sodium reabsorption in the ascending limb of the loop of Henle. This is shown by a marked reduction in freewater clearance during hydration and tubular solute-free water reabsorption during hydropenia. Bumetanide may have an additional action in the proximal tubule, since phosphaturia has been observed during…