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BLEOMYCIN SULFATE USP Faulding Antineoplastic Action And Clinical Pharmacology: Experiments with isolated DNA have shown that bleomycin binds to the DNA molecule and cleaves it. This results in the inhibition of DNA synthesis. There is also evidence of lesser inhibition of RNA and protein synthesis. Bleomycin exhibits a wide spectrum of in vitro and in vivo activity. It demonstrates inhibition of DNA synthesis in E. coli, B. subtilis, Ehrlich ascites…

BIOLON™ Ophtapharma Sodium Hyaluronate Ophthalmosurgical Aid Action And Clinical Pharmacology: Sodium hyaluronate is a physiological material found in both animal and human tissues. It is a polysaccharide consisting of a repeating disaccharide of N-acetylglucosamine and sodium glucuronate, linked by alternating b-1,3 and b-1,4 glycosidic bonds. Chemically identical in all species, hyaluronate can be found in the vitreous and aqueous humor of the eye, in synovial fluid, in skin and in…

BILTRICIDE® Bayer Praziquantel Anthelmintic Action And Clinical Pharmacology: Mechanism of Action: Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An increased calcium influx may play an important role. Secondary effects are inhibition of glucose uptake, lowering of…

BIONET® Carter Horner Benzocaine – Bicetonium Local Anti-infective – Analgesic Indications And Clinical Uses: The symptomatic treatment of mild infection and relief of pain in gum, pharyngeal, tonsillar and other oral disorders such as aphthous ulcers, stomatitis and gingivitis. May also be used postoperatively in tonsillectomy, dental surgery and tooth extraction. Contra-Indications: Benzocaine sensitivity. Precautions: Severe or persistent sore throat accompanied by high fever, headache, nausea and vomiting may be…

BIQUIN DURULES® Astra Controlled Release Quinidine Bisulfate Antiarrhythmic Agent Action And Clinical Pharmacology: Quinidine is a class IA antiarrhythmic agent according to the modified Vaughan-Williams classification. Quinidine is considered a myocardial depressant. Direct actions on the heart include: decreased myocardial excitability; prolongation of the atrial, ventricular and Purkinje refractory periods; decreased atrial, Purkinje and ventricular conduction velocities; substantially decreased firing rate of cardiac Purkinje fibres by direct action; decreased myocardial…

BICILLIN® L-A Wyeth-Ayerst Penicillin G Benzathine Antibiotic Action And Clinical Pharmacology: Actions: Penicillin G exerts a bactericidal action against penicillin-sensitive microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall mucopeptide. It is not active against the penicillinase-producing bacteria, which include many strains of staphylococci. Penicillin G exerts high in vitro activity against staphylococci (except penicillinase-producing strains), streptococci (Groups A,C,G,H,L and M) and pneumococci….

BICHLORACETIC ACID® Glenwood Dichloroacetic Acid Escharotic – Keratolytic Action And Clinical Pharmacology: Dichloroacetic acid rapidly penetrates and cauterizes skin, keratin and other tissues. Its cauterizing effect is comparable to that obtained with such methods as electrocautery or freezing. Indications And Clinical Uses: For all types of verrucae; calluses; hard and soft corns; xanthoma palpebrarum; seborrheic keratoses; ingrown nails; cysts and benign erosion of the cervix including endocervicitis; epistaxis. Contra-Indications: Should…

BiCNU® Bristol Carmustine Antineoplastic Agent Action And Clinical Pharmacology: Carmustine alkylates DNA and RNA and has been shown to inhibit several enzymes by carbamoylation of amino acids in proteins. In a series of in vivo and in vitro experiments with formate 4, adenine-8-4 and DL-leucine-4,5-, Wheeler and Bowdon obtained results indicating that carmustine interferes with the de novo synthesis of purine nucleotides and with the conversion of purine nucleotides to…

BEZALIP® Roche Bezafibrate Lipid Metabolism Regulator Action And Clinical Pharmacology: The fibrates, including bezafibrate, lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates (including bezafibrate) increase the high density lipoprotein (HDL) cholesterol fraction. Due to their major action on lipoprotein and hepatic triglyceride lipase, the fibrates appear to produce a…

BIAXIN® Abbott Clarithromycin Antibiotic Note: When used in combination with acid antisecretory drugs and other antimicrobials for the eradication of helicobacter pylori, the product monograph for those agents should be consulted. Action And Clinical Pharmacology: General: Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunit of susceptible bacteria and suppressing protein synthesis. Eradication of H. pylori: H. pylori is now established as a major etiological factor in…