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BUSPAR® Bristol Buspirone HCl Anxiolytic Action And Clinical Pharmacology: Buspirone is a psychotropic drug with selective anxiolytic properties which belongs chemically to the class of compounds known as the azaspirodecanediones, not chemically or pharmacologically related to benzodiazepines. Buspirone shares some of the properties of the benzodiazepines and the neuroleptics, as well as demonstrating other pharmacological action. Buspirone attenuates punishment suppressed behavior in animals and exerts a taming effect, but is…

BUTISOL® SODIUM Carter Horner Butabarbital Sodium Sedative – Hypnotic Indications And Clinical Uses: A daytime sedative when mild sedation is required for relief of symptoms of anxiety or tension resulting from emotional, physical, or situational stress. May be used in such conditions as: neuroses and anxiety-tension states, functional gastrointestinal disorders, peptic ulcer, menopausal syndrome, premenstrual tension, hyperthyroidism, essential hypertension, coronary artery disease, congestive heart failure, preoperative apprehension and insomnia. Contra-Indications:…

BREVICON® 0.5/35 Searle Norethindrone – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. tag_IndicationsIndications Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis…

BRICANYL® Tablets BRICANYL® TURBUHALER® Astra Terbutaline Sulfate Bronchodilator Action And Clinical Pharmacology: Terbutaline produces bronchodilation by stimulation of the B2 adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of muscle fibres. This action is manifested by an increase in pulmonary function as demonstrated by FEV1 measurements. Terbutaline also produces a decrease in airway and pulmonary resistance. Following inhalation of terbutaline Turbuhaler, a significant improvement in pulmonary function measurements is…

BRIETAL SODIUM® Lilly Methohexital Sodium Anesthetic Action And Clinical Pharmacology: Compared with thiamylal and thiopental, methohexital is at least twice as potent on a weight basis, and its duration of action is only about half as long. Although the metabolic fate of methohexital in the body is not clear, the drug does not appear to concentrate in fat depots to the extent that other barbiturate anesthetics do. Thus, cumulative effects…

BRONALIDE® Boehringer Ingelheim Flunisolide Corticosteroid Aerosol Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and anti-allergic activity in classical test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. When inhaled at therapeutic doses it has potent anti-inflammatory activity locally on the bronchial mucosa. Following i.v. administration in man of 2 mg flunisolide, plasma concentrations of 12 to…

Botulism Antitoxin Trivalent Types A, B and E (Equine) Connaught Antitoxin Indications And Clinical Uses: Experimental evidence concerning the amount of circulating antitoxin needed to counteract botulism toxin poisoning by antitoxin therapy is not fully documented. The outcome of treatment depends, as it does in other comparable conditions, largely on the time interval elapsing after onset of symptoms before the peak of absorbed antitoxin is reached. This principle is illustrated…

BRETYLATE® Glaxo Wellcome Bretylium Tosylate Antiarrhythmic Action And Clinical Pharmacology: Bretylium is an adrenergic-neurone blocking agent. The mechanism by which it exerts its antiarrhythmic action is not fully understood. Although evidence has indicated that the benefit of bretylium in abating tachyarrhythmias may be due to its antiadrenergic properties, this has still not been firmly established. Some reports have even indicated that there is a clear-cut dissociation between the neuron-blocking and…

BREVIBLOC® Zeneca Esmolol HCl Beta-adrenergic Receptor Blocking Agent Action And Clinical Pharmacology: Esmolol is a beta-adrenergic receptor blocking agent with predominant blocking effect on beta-1 receptors. It does not possess significant intrinsic sympathomimetic or membrane stabilizing activity. Esmolol, which is administered only i.v., has a rapid onset and a short duration of action. Pharmacodynamics: In human electrophysiology studies, esmolol produced effects typical of a beta-blocker: a decrease in the heart…

BLOCADREN® Frosst Timolol Maleate Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Timolol is a beta-adrenergic receptor blocking agent. The mechanism of the antihypertensive effect of beta- adrenergic receptor blocking agents has not yet been established. Among the factors that may be involved are: competitive ability to antagonize catecholamine-induced tachycardia at the beta receptor sites in the heart, thus decreasing cardiac output; inhibition of renin release by the kidneys; inhibition…