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COVERSYL® Servier Perindopril Erbumine Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Perindopril is a nonsulphydryl angiotensin-converting enzyme (ACE) inhibitor, which is used in the treatment of hypertension. Following oral administration, perindopril is rapidly hydrolyzed to perindoprilat, its principal active metabolite. Angiotensin-converting enzyme catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE activity leads…

CREO-RECTAL® Nadeau Diphenylpyraline HCl – Camphor – Guaiacol Expectorant – Antihistaminic Indications And Clinical Uses: For the temporary relief of coughs due to colds, bronchitis, bronchial asthma. Contra-Indications: Hypersensitivity to any of the components. Precautions: Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or other drugs with CNS…

CREON® 10 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea, post-pancreatectomy, post-gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Perianal irritation, and rarely, inflammation, could occur…

CREON® 25 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea and postpancreatectomy, post gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Pregnancy and Lactation: There is…

COSMEGEN® MSD Dactinomycin Antineoplastic Action And Clinical Pharmacology: Dactinomycin is an antibiotic obtained as the principal component of the mixture of actinomycins produced by S. parvullus. This organism, unlike other species, yields an essentially pure substance that contains only traces of similar compounds differing in the amino acid content of the peptide side chains. It is available for clinical use as a sterile, yellow lyophilized powder which, in aqueous solution,…

CORTROSYN® Organon Cosyntropin Adrenocorticotropic Hormone Action And Clinical Pharmacology: The pharmacologic profile of cosyntropin is similar to that of purified natural ACTH, it has been established that 250 µg of cosyntropin will stimulate the adrenal cortex maximally and to the same extent as 25 units of natural ACTH. These clinical observations confirm earlier animal and assay studies establishing the 1:100 ratio. This dose of cosyntropin will produce maximal secretion of…

COTAZYM® Organon Pancrelipase Preparations Enzymes – Digestant Indications And Clinical Uses: Pancreatic enzyme replacement therapy in established pancreatic insufficiency where pancreatic enzymes are absent from or present in insufficient amount in the intestine: pancreatectomy, chronic pancreatitis, cystic fibrosis, steatorrhea and other malabsorption syndromes in which fat digestion is inadequate because of deficiency of pancreatic enzymes. Contra-Indications: Allergy to porcine protein. Manufacturers’ Warnings In Clinical States: In the event that capsules…

COUMADIN® DuPont Pharma Warfarin Sodium Anticoagulant Action And Clinical Pharmacology: Warfarin and other coumarin anticoagulants act by inhibiting the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. Half-lives of these clotting factors are as follows: Factor II – 60 hours, VII – 4 to 6 hours, IX – 24 hours, and X – 48 to 72…

CORTISPORIN® Glaxo Wellcome Hydrocortisone – Neomycin – Polymyxin B Compound Anti-inflammatory – Antibacterial Action And Clinical Pharmacology: Corticosteroids suppress the inflammatory response to a variety of agents and they may delay healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case. The anti-infective components in the combination are included…

CORTONE® Suspension MSD Cortisone Acetate Corticosteroid Action And Clinical Pharmacology: Cortisone is a natural product of the adrenal cortex. Cortisone is a synthetic steroid with the basic actions and effects of other glucocorticoids. Cortisone sterile suspension has a slow onset but long duration of action when compared with more soluble preparations. When daily corticosteroid therapy is required and oral therapy is not feasible, the required daily dosage may be given…