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FELDENE™ Pfizer Piroxicam Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Piroxicam is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action is incompletely known. Piroxicam inhibits the activity of prostaglandin synthetase. The resulting decrease in prostaglandin biosynthesis may partially explain its anti-inflammatory action. Piroxicam does not act by pituitary-adrenal stimulation. In rheumatoid arthritis the efficacy of piroxicam 20 mg daily has been found to be similar…

FERMALAC® Rougier Lactobacillus Acidophilus Compound Flora Modifier Indications And Clinical Uses: The treatment of mild diarrhea and intestinal upset, particularly when associated with antibiotic therapy. Precautions: Store under refrigeration. Should not be used to prepare yogurt or acidophilus milk. Dosage: Adults: 1 to 2 capsules 3 times/day. Availability And Storage: Each No. 0 enteric coated capsule with opaque blue top and opaque white bottom contains: 1 billion fully viable bacilli…

FASTIN® SmithKline Beecham Phentermine HCl Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known…

FEIBA® VH IMMUNO Baxter Human Plasma Factor VIII Inhibitor Coagulant Complex Anti-inhibitor Description: Feiba VH Immuno, is a freeze-dried sterile human plasma fraction with Factor VIII inhibitor bypassing activity. In vitro, Feiba VH Immuno shortens the activated partial thromboplastin time (APTT) of plasma containing Factor VIII inhibitor. Factor VIII inhibitor bypassing activity is expressed in arbitrary units. One Immuno Unit of activity is defined as that amount of Feiba VH…

EVISTA™ Lilly Raloxifene HCl Selective Estrogen Receptor Modulator Action And Clinical Pharmacology: Raloxifene is a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. The SERM profile of raloxifene includes estrogen agonist effects on bone and lipid metabolism but not in uterine or breast tissues. Pharmacokinetics: The disposition of raloxifene has been evaluated in 276 postmenopausal women in conventional clinical pharmacology studies and in more than…

EXOSURF® NEONATAL Glaxo Wellcome Colfosceril Palmitate Synthetic Lung Surfactant Action And Clinical Pharmacology: Surfactant deficiency is an important factor in the development of the neonatal respiratory distress syndrome (RDS). Natural surfactant, a combination of lipids and apoproteins, exhibits not only surface tension reducing properties (conferred by the lipids), but also rapid spreading and adsorption (conferred by the apoproteins). The major fraction of the lipid component of natural surfactant is colfosceril…

FAMVIR™ SmithKline Beecham Famciclovir Antiviral Agent Action And Clinical Pharmacology: Famciclovir is the orally administered pro-drug of the antiviral agent penciclovir. Famciclovir itself has no antiviral activity until it is biotransformed to penciclovir. Following oral administration little or no famciclovir is detected in plasma or urine since famciclovir is rapidly converted via deacetylation and oxidation to penciclovir. Studies in volunteers have shown that famciclovir is well absorbed and produces plasma…

EUMOVATE® Glaxo Wellcome Clobetasone 17-butyrate Topical Corticosteroid Action And Clinical Pharmacology: The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasone are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, anti-puritic, and vasoconstrictive actions. However while the physiologic, pharmacologic…

EUGLUCON® Pharmascience Glyburide Oral Hypoglycemic Indications And Clinical Uses: To control hyperglycemia in glyburide responsive diabetes mellitus of stable, mild, nonketosis prone, maturity-onset or adult type which cannot be controlled by proper dietary management and exercise, or when insulin therapy is not appropriate. Contra-Indications: Known hypersensitivity or allergy to glyburide; unstable and/or insulin-dependent diabetes mellitus; ketoacidosis; coma; stress conditions such as severe infections, trauma or surgery; the presence of jaundice,…

EURAX® Novartis Consumer Health Crotamiton Antipruritic Indications And Clinical Uses: To relieve itching in most types of dermatosis, notably: atopic dermatitis, chickenpox, contact dermatitis, creeping eruption, dermatitis herpetiformis, dermatitis medicamentosa, dermatophytosis, eczema, insect bites, intertrigo, lichen planus, neurodermatitis, neurotic excoriation, pityriasis rosea, poison ivy dermatitis, pruritus ani, scroti and vulvae, psoriasis, seborrheic dermatitis, senile pruritus, sunburn, urticaria, varicose eczema. Contra-Indications: Acutely inflamed skin or raw, weeping areas. Hypersensitivity to crotamiton….