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ENTOCORT® Enema Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency. It undergoes an extensive degree (approximately 90%) of biotransformation in the liver to metabolites with low glucocorticosteroid activity. The glucocorticosteroid activity of the major metabolites, 6b-hydroxybudesonide and 16a-hydroxyprednisolone, is less than 1% of that of budesonide. The favorable separation between…

ENFALAC PREGESTIMIL® Mead Johnson Protein Hydrolysate Formula Pediatric Elemental Diet Indications And Clinical Uses: For feeding of infants and children with malabsorption problems which may include: disaccharidase deficiency (relative or absolute), idiopathic defects in digestion or absorption, steatorrhea, cystic fibrosis, food allergies and intestinal resection. Precautions: Patients with lengthy episodes of diarrhea and/or receiving antibiotics may require supplemental vitamin K. In a few instances, premature infants and infants with long-standing…

ENFALAC PROSOBEE® Mead Johnson Soy Protein Isolate Hypoallergenic Product Indications And Clinical Uses: Formula for feeding infants or children with a sensitivity to cow milk protein or a family history of allergies. Symptoms that may require a milk-free source of nutrition include the following: persistent and unexplained eczema, diarrhea, non-specific respiratory disorders, spitting up, and irritability. May be used for adults with food allergies. Precautions: Opened or prepared formula should…

ENLON® Zeneca Edrophonium Chloride Nondepolarizing Neuromuscular Antagonist Action And Clinical Pharmacology: Edrophonium chloride is an anticholinesterase agent which antagonizes the action of nondepolarizing neuromuscular blocking drugs. Edrophonium chloride inactivates the enzyme acetylcholinesterase by combining with it in a reversible manner. The inactivation of the enzyme prevents the hydrolysis of acetylcholine and allows the accumulation of the neurotransmitter. The accumulation of acetylcholine at cholinergic receptor sites leads to the resumption of…

EMLA® Cream/Patch Astra Lidocaine – Prilocaine Topical Anesthetic for Dermal Analgesia Action And Clinical Pharmacology: EMLA (Eutectic Mixture of Local Anesthetics) is a 1:1 oil/water emulsion of a eutectic mixture of lidocaine and prilocaine bases. Dermal analgesia is a result of the migration of lidocaine and prilocaine into the epidermal and dermal layers of the skin followed by the accumulation of these agents in the vicinity of dermal pain receptors…

ENFALAC LYTREN® Mead Johnson Oral Electrolyte Solution Electrolyte Replacement Indications And Clinical Uses: Oral administration of electrolyte replacement for infants and children who have experienced electrolyte and fluid loss due to mild or moderate diarrhea and who do not require parenteral therapy. Contra-Indications: Do not use in the presence of severe, continuing diarrhea or other critical fluid losses requiring parenteral fluid therapy; in intractable vomiting, adynamic ileus, intestinal obstruction or…

EMPRACET® -30 EMPRACET® -60 Glaxo Wellcome Acetaminophen – Codeine Phosphate Analgesic – Antipyretic – Antitussive Action And Clinical Pharmacology: Acetaminophen is in the category of an analgesic and antipyretic, codeine is in the category of analgesic and antitussive. Codeine retains at least one-half of its analgesic activity when administered orally. tag_IndicationsIndications Indications And Clinical Uses: Empract-30: For relief of mild to moderate pain. Empract-60: For relief of moderate to severe…

EMCYT® Pharmacia & Upjohn Estramustine Sodium Phosphate Antineoplastic Action And Clinical Pharmacology: Estramustine has a dual mode of action. The intact molecule acts as an antimitotic agent and after hydrolysis of the carbamate ester bridge the released estrogens exert an antigonadotrophic effect. The low level of clinically manifested side effects may be due to the fact that estramustine binds to a protein present in the tumor tissue, which results in…

ELDISINE® INJECTION Lilly Vindesine Sulfate Antineoplastic Action And Clinical Pharmacology: The mode of action of vindesine is not completely understood. Like the other vinca alkaloids, vinblastine sulfate (Velbe) and vincristine sulfate (Oncovin), vindesine causes arrest of cells in metaphase mitosis. In addition, in vitro investigation has demonstrated that vindesine prevents invasion of normal tissue by malignant cells. Comparative studies with these 3 alkaloids, however, demonstrate differences in their effect at…

ELOCOM Schering Mometasone Furoate Corticosteroid Action And Clinical Pharmacology: Mometasone has anti-inflammatory, antipruritic and vasoconstrictive actions. The exact mechanism, however, of corticosteroids in each disease is uncertain. Mometasone has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs. Indications And Clinical Uses: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as psoriasis and atopic dermatitis. The…