You searched for : 'C'

FORTAZ® Glaxo Wellcome Ceftazidime Pentahydrate Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftazidime, a semisynthetic cephalosporin antibiotic, results from inhibition of bacterial cell wall synthesis. Ceftazidime has a high affinity for the Penicillin-Binding Protein-3 (PBP-3) and moderate affinity for the PBP-1a of certain gram-negative organisms such as E. coli and P. aeruginosa. The affinity for PBP-1b is much less than that for either…

FOLIC ACID * General Monograph, Pteroylglutamic Acid Folate Sodium Anemia Therapy Pharmacology: Folic acid is a B complex vitamin. After absorption from the gastrointestinal tract, folic acid is hepatically converted to tetrahydrofolic acid which is a cofactor in the biosynthesis of purines and thymidylates of nucleic acids. An exogenous source of folic acid is necessary for the maintenance of normal erythropoiesis. Folic acid deficiency can lead to meagloblastic and macrocytic…

FLUZONE® Connaught Influenza Virus Vaccine Trivalent Types A and B (Zonal Purified, Subvirion) Active Immunizing Agent Action And Clinical Pharmacology: The inoculation of antigen prepared from inactivated influenza virus stimulates the production of specific antibodies. Protection is afforded only against those strains of virus from which the vaccine is prepared or closely related strains. Influenza A viruses are classified into subtypes on the basis of 2 surface antigens: hemagglutinin (H)…

FLUOROURACIL ROCHE® Roche 5-Fluorouracil Antineoplastic Caution: 5-fluorouracil is a potent drug and should be prescribed only by physicians experienced with cancer chemotherapeutic drugs (see Precautions). Blood counts as well as renal and hepatic function tests should be performed regularly. Discontinue the drug if there is significant leukopenia (under 3 000/mm or granulocytopenia (under 1 500/mm. Action And Clinical Pharmacology: 5-Fluorouracil is a fluorinated pyrimidine antimetabolite which is structurally similar to…

FLUOTIC® Hoechst Marion Roussel Sodium Fluoride Otospongiosis Therapy Action And Clinical Pharmacology: Sodium fluoride acts partly by reducing bone resorption in the bone remodeling cycle and partly by increasing bone deposition. In organ culture of otospongiotic bone removed at operation, sodium fluoride increased radioactive calcium uptake. Analysis of the fluoride content of otospongiotic bone showed a higher fluoride content in untreated patients, than in the endochrondral bone of the noninvolved…

FLOVENT® Glaxo Wellcome Fluticasone Propionate Corticosteroid Action And Clinical Pharmacology: Fluticasone is a highly potent glucocorticoid anti-inflammatory steroid with strong topical and negligible systemic activity. When administered by inhalation at therapeutic dosages, it has a direct potent anti-inflammatory action within the lungs, resulting in reduced symptoms and exacerbations of asthma without the adverse effects observed when corticosteroids are administered systemically. In comparisons with beclomethasone dipropionate, fluticasone propionate has demonstrated greater…

FLORINEF® Roberts Fludrocortisone Acetate Addison’s Disease Therapy Action And Clinical Pharmacology: The physiologic action of fludrocortisone is similar to that of hydrocortisone. However, the effects of fludrocortisone, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. In small oral doses, fludrocortisone produces marked sodium retention and increased urinary potassium excretion. It also causes a rise in blood pressure, apparently because of these effects on electrolyte…

FLOXIN® Janssen-Ortho Ofloxacin Antibacterial Action And Clinical Pharmacology: Ofloxacin is a broad-spectrum, synthetic fluoroquinolone antibacterial agent for oral administration. Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting the essential bacterial enzyme, DNA gyrase, a critical catalyst in the duplication, transcription and repair of bacteria. Pharmacokinetics: The pharmacokinetic profile of ofloxacin tablets is comparable to the profile of ofloxacin administered i.v. The bioavailability of ofloxacin…

FLUANXOL® DEPOT INJECTION FLUANXOL® TABLETS Lundbeck Flupenthixol Decanoate Flupenthixol Dihydrochloride Antipsychotic Action And Clinical Pharmacology: Flupenthixol is the decanoate ester of a thioxanthene derivative with antipsychotic properties. The esterification of flupenthixol results in the slow release of the drug from the injection site with consequent prolongation of duration of action. The onset of action usually occurs in the range of 24 to 72 hours after injection and the improvement of…

FLEXERIL® Frosst Cyclobenzaprine HCl Skeletal Muscle Relaxant Action And Clinical Pharmacology: Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to CNS disease. Controlled clinical studies show that cyclobenzaprine improves the signs and the symptoms of skeletal muscle spasm. Pharmacokinetics: Cyclobenzaprine is well absorbed in man. After oral or i.v. doses (10 mg) of 4-labeled cyclobenzaprine to human subjects,…