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TAXOL™ Bristol-Myers Squibb Paclitaxel Antineoplastic Agent Caution: Paclitaxel should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel should be pretreated with corticosteroids, antihistamines, and H 2 antagonists (such as dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). Severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients…

TAMOFEN® Rh´ne-Poulenc Rorer Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to is ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In…

TAMONE® Pharmacia & Upjohn Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA), and causes the regression of already established DMBA-induced tumors….

TYLENOL® COUGH MEDICATION McNeil Consumer Healthcare Acetaminophen-Dextromethorphan HBR Analgesic-Antipyretic-Antitussive Indications And Clinical Uses: For the temporary relief of dry cough, sore throat, aches, pains and fever. Contra-Indications: Known hypersensitivity to acetaminophen and/or pressor amines. Patients receiving or having received MAO inhibitors in the preceding 2 weeks. Although pseudoephedrine is virtually without pressor effect in normotensive patients, it should be used with caution in hypertensive individuals.: Precautions: As with any other…

TYLENOL® ACHES AND STRAINS MEDICATION McNeil Consumer Healthcare Acetaminophen-Chlorzoxazone Analgesic-Muscle Relaxant Action and Clinical Pharmacology: Tylenol Aches and Strains Medication combines the muscle-relaxant effect of chlorzoxazone with acetaminophen, a well known analgesic.: Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments, as well as human study, indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where…

TUSSIONEX® Rhône-Poulenc Rorer Hydrocodone (Resin Complex)–Phenyltoloxamine (Resin Complex) Antitussive–Antihistamine Action and Clinical Hydrocodone is a semi-synthetic narcotic antitussive and analgesic with multiple actions qualitatively similar to those of codeine. As an antitussive, hydrocodone is approximately 3 times as potent as codeine on a weight for weight basis. The precise mechanism of action of hydrocodone and other opiates is not known; however, hydrocodone is believed to inhibit coughing by interfering with…

SYNACTHEN® DEPOT Novartis Pharmaceuticals Cosyntropin Zinc Hydroxide Adrenocorticotropic Hormone Action and Clinical Natural adrenocorticotropin is a straight-chain polypeptide containing 39 amino acids which, by convention, are numbered from the N terminal end of the molecule. The sequence of amino-acid occupying positions 25 to 33 varies among species and it is this part of the molecule which is most antigenic when ACTH of foreign origin is administered to man. In contrast,…

SUPLASYN® Paladin Sodium Hyaluronate Synovial Fluid Replacement Action and Clinical Hyaluronic acid is a naturally occurring mucopolysaccharide present in the connective tissue of all animals. It is a biological polymer composed of repeating units of two sugars, D-glucuronic acid and N-acetylglycosamine, linked by glycosidic bonds. This configuration for hyaluronic acid is the same for all living species from bacteria to man. High concentrations are found in synovial fluid, the vitreous…

SUPRAX® Rhône-Poulenc Rorer Cefixime Antibiotic Action and Clinical Pharmacology: Cefixime exerts its bactericidal effect by attaching to penicillin-binding proteins and inhibiting peptidoglycan synthesis, thus causing damage to the bacterial cell wall.: Pharmacokinetics: Following oral dosing, cefixime attains peak serum levels in approximately 4 hours. The half-life is about 3 to 4 hours and is not dose dependent. Cefixime is excreted by renal and biliary mechanisms. About 50% of the absorbed dose is excreted…

SULFOXYL® Stiefel Sulfur-Benzoyl Peroxide Acne Vulgaris Therapy Availability And Storage: Each mL of lotion contains: sulfur 2% and benzoyl peroxide 5% in a vanishing lotion base. Nonmedicinal ingredients: glyceryl monostearate, imidurea, isopropyl palmitate, PEG 1000 monostearate, propylene glycol, purified water, stearic acid, xantham gum and zinc stearate. Plastic bottles of 60 mL. Protect from heat. SULFOXYL® Stiefel Sulfur–Benzoyl Peroxide Acne Vulgaris Therapy