RxMed: Pharmaceutical Information – SUPLASYN

SUPLASYN® Paladin Sodium Hyaluronate Synovial Fluid Replacement

Action and Clinical

Hyaluronic acid is a naturally occurring mucopolysaccharide present in the connective tissue of all animals. It is a biological polymer composed of repeating units of two sugars, D-glucuronic acid and N-acetylglycosamine, linked by glycosidic bonds. This configuration for hyaluronic acid is the same for all living species from bacteria to man. High concentrations are found in synovial fluid, the vitreous humor of the eye, cartilage, connective tissue and the umbilical cord. Hyaluronic acid functions as a viscoelastic support to maintain separation between tissues, as a tissue and joint lubricant, and is thought to play an important role in modulating the interactions between adjacent tissues.

Suplasyn is a highly purified sodium salt of hyaluronic acid, with a defined molecular chain length (2 500 to 3 500 saccharide units) and molecular weight (500 to 730 kDa). Suplasyn is nonantigenic, nonpyrogenic and does not cause inflammation of foreign body reactions. The viscoelastic properties of Suplasyn are similar to that of synovial fluid. The introduction of Suplasyn into the synovial space will assist in the normalization of the function and rheological properties of the joint.

Indications and Clinical Uses:

As a replacement for synovial fluid following arthrocentesis.

Contra-Indications:

When used as indicated, there are no known contraindications to the use of sodium hyaluronate.

Precautions:

Do not administer to patients with known hypersensitivity reactions. Transient, short duration pain or swelling may occur following intra-articular injections of sodium hyaluronate.:

Adverse Reactions:

:Sodium hyaluronate is the salt of a natural component of many of the tissues of the body. It is extremely well tolerated when injected into the intra-articular space. Reports of minor inflammation have been reported but are generally considered to be due to the method of administration. Each batch of Suplasyn is tested in vivo to confirm its essential noninflammatory properties.DosageDosage

Dosage And Administration:

Depending upon joint size, up to 2 mL may be administered intra-articularly. The recommended schedule is 3 weekly injections, but up to 6 may be given in chronic conditions. Using aseptic technique, introduce up to 2 mL intra-articularly into the affected joint. More than one joint may be treated at the same time. Discard any unused portion of the vial.

Availability And Storage:

Each mL of sterile, viscoelastic solution for intra-articular injection contains: sodium hyaluronate 10 mg (hyaluronic acid sodium salt). Vials of 2 mL, boxes of 3. Store at room temperature (15 to 30°C). Do not freeze.

SUPLASYN® Paladin Sodium Hyaluronate Synovial Fluid Replacement