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TIMOPTIC®, TIMOPTIC-XE® Merck Frosst Timolol Maleate Elevated Intraocular Pressure Therapy Action and Clinical Timolol is a general beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant or local anesthetic (membrane-stabilizing) activity. Timolol combines reversibly with a part of the cell membrane, the beta-adrenergic receptor, and thus inhibits the usual biologic response that would occur with stimulation of that receptor. This specific competitive antagonism blocks stimulation…

THIOTEPA Wyeth-Ayerst Cytotoxic Agent Action and Clinical Uses: Thiotepa is a cytotoxic agent of the polyfunctional alkylating type (more than one reactive ethylenimine group) related chemically and pharmacologically to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs…

TETANUS AND DIPHTHERIA TOXOIDS ADSORBED (Td Adsorbed) Connaught Active Immunizing Agent Action and Clinical Tetanus is an acute and often fatal disease caused by an extremely potent neurotoxin produced by C. tetani. The organism is ubiquitous and its occurrence in nature cannot be controlled. Immunization is highly effective, produces long-lasting protection and is recommended for the whole population. Only 2 to 3 cases of tetanus are now reported annually in Canada….

TETANUS TOXOID ADSORBED Connaught Vaccine Indications And Clinical Uses: For primary and secondary immunization against tetanus. Contra-Indications: Immunization with Tetanus Toxoid Adsorbed should be deferred in the presence of any acute illness, including febrile illness. Warnings in Clinical States: Elective immunization should be deferred during an outbreak of poliomyelitis. Individuals receiving corticosteroids or other immunosuppressive drugs may not develop an optimum immunologic response. Precautions: The possibility of allergic reactions in…

TEGOPEN® Bristol Cloxacillin Sodium Antibiotic Action and Clinical Cloxacillin is a penicillinase-resistant, acid resistant, semi-synthetic penicillin. Cloxacillin exerts a bactericidal action against susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptides.: Cloxacillin is readily absorbed following i.m. administration and rapidly reaches therapeutically effective blood levels. Serum levels are approximately proportional to dosage. Peak plasma concentrations of 15 g/mL have been…

TEARS NATURALE® FREE Alcon Dextran 70–Hydroxypropyl Methylcellulose Artificial Tears Availability & Storage: Each mL of sterile, isotonic solution contains: 0.1% dextran 70 and hydroxypropyl methylcellulose 0.3%. Preservative-free. Nonmedicinal ingredients: hydrochloric acid, potassium chloride, purified water, sodium borate, sodium chloride and sodium hydroxide. Unit dose containers of 0.6 mL. Boxes of 24. TEARS NATURALE® FREE Alcon Dextran 70–Hydroxypropyl Methylcellulose Artificial Tears

TEARS NATURALE® Alcon Dextran 70–Hydroxypropyl Methylcellulose Artificial Tears Availability And Storage: A sterile, buffered, isotonic solution of dextran 70 0.1% and hydroxypropyl methylcellulose 0.3%. Preservative: benzalkonium chloride. Nonmedicinal ingredients: edetate disodium, hydrochloric acid, potassium chloride, purified water, sodium chloride and sodium hydroxide. Drop-Tainer dispensers of 15 or 30 mL. TEARS NATURALE® Alcon Dextran 70–Hydroxypropyl Methylcellulose Artificial Tears

TAXOTERE® Rhône-Poulenc Rorer Docetaxel Antineoplastic Caution: Docetaxel concentrate for injection should be administered under the supervision of a physician experienced in the use of antineoplastic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. Docetaxel therapy should not be given to patients with neutrophil counts of less than 1 500 cells/mm Severe hypersensitivity reactions resulting in immediate discontinuations occurred in 0.4% (5…

Td POLIO ADSORBED (Tetanus and Diphtheria Toxoids Adsorbed and Inactivated Poliomyelitis Vaccine) Connaught Active Immunizing Agent Action and Clinical Pharmacology Tetanus is an acute and often fatal disease caused by an extremely potent neurotoxin produced by C. tetani. The organism is ubiquitous and its occurrence in nature cannot be controlled. Immunization is highly effective, produces long-lasting protection and is recommended for the whole population. Only 2 to 3 cases of…

TARO-DESOXIMETASONE Taro Desoximetasone Topical Corticosteroid Action and Clinical Pharmacology: Desoximetasone cream is a potent fluorinated corticosteroid. Topical corticosteroids are synthetic derivatives of cortisone which are effective when applied locally to control many types of inflammatory, allergic and pruritic dermatoses. Modifications to the chemical structure, such as fluorination, generally enhance both anti-inflammatory activity and increase the likelihood of adverse effects. The mechanism of anti-inflammatory activity of topical corticosteroids is generally unclear….