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XANAX® XANAX TS Pharmacia & Upjohn Alprazolam Anxiolytic – Antipanic Action And Clinical Pharmacology: Alprazolam, a triazolo 1,4 benzodiazepine analog, binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex. Pharmacokinetics: Orally administered alprazolam is readily absorbed in man. Plasma levels are proportional to the dose given; over the dose range of…

XYLOCAINE® DENTAL SOLUTIONS Astra Lidocaine HCl – Epinephrine Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within sodium channels of the nerve membrane. Onset of Action: When used for infiltration anesthesia in dental patients, the onset…

XYLOCAINE® ENDOTRACHEAL Astra Lidocaine HCl Topical Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within the sodium channels of the nerve membrane. Onset of Action: Lidocaine, when applied topically to the oral cavity, acts on mucous membranes…

X-PREP® Purdue Frederick Standardized Sennosides Diagnostic Aid Indications And Clinical Uses: A potent cathartic to be used only for evacuation of the colon prior to contrast radiography of the gastrointestinal tract, other abdominal radiography, or examinations where a clear colon is essential for proper visualization. Also indicated prior to surgery of the colon or rectum. Contra-Indications: The “acute abdomen”. Dosage And Administration: Adults: At 10 a.m. on the day prior…

XALATAN™ Pharmacia & Upjohn Latanoprost Prostaglandin F2  Analogue Action And Clinical Pharmacology: Latanoprost, a novel prostaglandin F2  analogue, is a selective prostanoid FP receptor agonist which reduces the intraocular pressure by increasing the outflow of aqueous humor. Studies in animals and man indicate that the main mechanism of action is increased uveoscleral outflow. Primary open-angle glaucoma is a disease with characteristic optic nerve damage and a corresponding visual field defect….

WARTEC® Pharmascience Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is a metaphase inhibitor of dividing cells. Podofilox binds to at least one binding site on tubulin. This binding prevents the tubulin polymerization required for microtubule assembly. At higher concentrations podofilox also inhibits nucleoside transport through the cell membrane. The…

VIVONEX® PLUS Novartis Nutrition High Nitrogen Elemental Diet Indications And Clinical Uses: A high nitrogen, elemental (100% free amino acids) diet for patients with impaired digestion and absorption. Contains enhanced glutamine, arginine and branched chain amino acid content, especially useful in stressed catabolic patients. Suggested indications include: inflammatory bowel disease, intestinal atresia, pancreatitis, fistula, partial obstruction, short-gut syndrome. Malnutrition and cachexia. Bowel preparation prior to diagnostic and surgical procedures. Transition…

VIVONEX® T.E.N. Novartis Nutrition Elemental Diet Indications And Clinical Uses: A high nitrogen, elemental (100% free amino acids) diet enriched with glutamine for patients with impaired digestion or absorption. Suggested indications include: inflammatory bowel disease, intestinal atresia, pancreatitis, fistula, partial obstruction, short-gut syndrome. Malnutrition and cachexia. Bowel preparation prior to diagnostic and surgical procedures. Transition diet between parenteral and normal oral feeding. Food sensitivities. Precautions: Do not administer parenterally. For…

VIVONEX® PEDIATRIC Novartis Nutrition Pediatric Elemental Diet Indications And Clinical Uses: Use in the dietary management of children with clinical conditions of short bowel syndrome, inflammatory bowel disease, malabsorption syndrome, cow’s milk protein enteropathy/sensitivity, select multiple trauma/major surgery, Crohn’s disease, gastrointestinal fistula, select pre/post surgery, intractable diarrhea and gastrointestinal disorder related to HIV/AIDS. Precautions: Do not administer parenterally. For use only under medical supervision. Nausea, vomiting, abdominal cramps, distention and…

VISIPAQUE™ Nycomed Imaging A.S. Iodixanol Nonionic Radiographic Contrast Medium Action And Clinical Pharmacology: Immediately following rapid intravascular injection, iodixanol reaches peak plasma concentration and is then rapidly distributed throughout the extracellular fluid compartment. It will opacify those vessels in the path of flow of the contrast medium, permitting radiographic visualization of the vasculature of the internal structures until significant dilution and elimination occurs. The degree of density enhancement is directly…