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FRAXIPARINE™ Sanofi Nadroparin Calcium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Nadroparin is a low molecular weight heparin. It is a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Of the low molecular weight heparins, nadroparin has the lowest mean molecular weight of approximately 4 300 daltons; 75 to 95% of the molecular masses are in…

FOSAMAX® MSD Alendronate Sodium Bone Metabolism Regulator Action And Clinical Pharmacology: Alendronate is an aminobisphosphonate that acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Pharmacokinetics: Absorption: Relative to an i.v. reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an…

FLOXIN® Janssen-Ortho Ofloxacin Antibacterial Action And Clinical Pharmacology: Ofloxacin is a broad-spectrum, synthetic fluoroquinolone antibacterial agent for oral administration. Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting the essential bacterial enzyme, DNA gyrase, a critical catalyst in the duplication, transcription and repair of bacteria. Pharmacokinetics: The pharmacokinetic profile of ofloxacin tablets is comparable to the profile of ofloxacin administered i.v. The bioavailability of ofloxacin…

FLUANXOL® DEPOT INJECTION FLUANXOL® TABLETS Lundbeck Flupenthixol Decanoate Flupenthixol Dihydrochloride Antipsychotic Action And Clinical Pharmacology: Flupenthixol is the decanoate ester of a thioxanthene derivative with antipsychotic properties. The esterification of flupenthixol results in the slow release of the drug from the injection site with consequent prolongation of duration of action. The onset of action usually occurs in the range of 24 to 72 hours after injection and the improvement of…

FLEXERIL® Frosst Cyclobenzaprine HCl Skeletal Muscle Relaxant Action And Clinical Pharmacology: Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to CNS disease. Controlled clinical studies show that cyclobenzaprine improves the signs and the symptoms of skeletal muscle spasm. Pharmacokinetics: Cyclobenzaprine is well absorbed in man. After oral or i.v. doses (10 mg) of 4-labeled cyclobenzaprine to human subjects,…

FLOMAX® Boehringer Ingelheim Tamsulosin HCl Selective Antagonist of Alpha1A-adrenoceptor Subtype in the Prostate Action And Clinical Pharmacology: Tamsulosin, an alpha1-adrenoceptor blocking agent, exhibits selectivity for alpha1 receptors in the human prostate. At least 3 discrete alpha1-adrenoreceptor subtypes have been identified: alpha1A, alpha1B and alpha1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptor in human prostate is of the alpha1A subtype. The symptoms associated with benign…

FLEXALL® Chattem Menthol Topical Analgesic Indications And Clinical Uses: For temporary relief from minor arthritis pain, bursitis, tendonitis, backache, strains and sprains. Warnings: For external use only. Keep out of the reach of children. Keep away from eyes, mucous membranes, broken or irritated skin. If rash occurs, discontinue use. Do not bandage tightly or use heating pad. Dosage: Apply generously to muscles and joints and gently massage until gel disappears….

FLEXALL® STICK Chattem Menthol – Methyl Salicylate Topical Analgesic Indications And Clinical Uses: For temporary relief from minor arthritis pain, bursitis, tendonitis, backache, strains and sprains. Manufacturers’ Warnings In Clinical States: For external use only. Keep out of the reach of children. Keep away from eyes, mucous membranes, broken or irritated skin. If rash or excessive irritation occurs, discontinue use. If condition worsens or persists for more than 7 days,…

FLAMAZINE® C Smith & Nephew Silver Sulfadiazine – Chlorhexidine Digluconate Topical Antibacterial Action And Clinical Pharmacology: The mechanism of silver sulfadiazine’s antibacterial action has not been fully elucidated. After exposure to the drug, structural changes in the bacterial cell membrane occur, including distortion and enlargement of the cell and a weakening of the cell wall membrane. This is accompanied by reduced viability in sensitive strains. The silver sulfadiazine molecule dissociates…

FLAREX® Alcon Fluorometholone Acetate Corticosteroid Action And Clinical Pharmacology: Adrenocorticoids suppress the inflammatory response (edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, deposition of collagen and scar formation) to chemical, immunological or mechanical irritants. Adrenocorticoids may cause a rise in intraocular pressure in susceptible individuals. They are absorbed into aqueous humor, cornea, iris, choroid, ciliary body, and retina. Systemic absorption occurs but may be significant only at higher doses…