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ISOTREX® Stiefel Isotretinoin Acne Therapy Action And Clinical Pharmacology: Isotretinoin is a drug known to improve cystic acne when taken orally. It has also shown similar activity when used for treating less severe forms of acne. While its mechanism of action is not known, studies have shown that oral isotretinoin can decrease sebum secretion and sebaceous gland size. It also affects the keratinization of the stratum corneum. These processes are…

ISOPRINOSINE® Rivex Pharma Inosiplex Subacute Sclerosing Panencephalitis Therapy Action And Clinical Pharmacology: Mechanism(s) that might explain the results of the clinical studies employing inosiplex have not been completely elucidated. However, possible antiviral and immunomodulating properties of this drug may be involved. Serum uric acid concentration rose with increasing inosiplex doses. Hyperuricemic levels (greater than 7.5 mg%) were seen at doses equal to or exceeding 3 g/day. At doses of 4…

IONAMIN® Rhône-Poulenc Rorer Phentermine (Resin Complex) Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drug of this class used in obesity, amphetamine (d- and dl-amphetamine). Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity…

INFUFER® Sabex Iron Dextran Hematinic – Iron Supplement Action And Clinical Pharmacology: After i.m. injection, iron dextran is absorbed from the injection site into the capillaries and the lymphatic system. Circulating iron dextran is dissociated by the reticuloendothelial system. The ferric iron is transported by transferrin and incorporated into hemoglobin and storage sites. Only traces of unmetabolized iron dextran are excreted in urine, bile or feces. The drug is negligibly…

IMITREX® Injection/Tablets IMITREX® Nasal Spray Glaxo Wellcome Sumatriptan Succinate Sumatriptan Migraine Therapy Action And Clinical Pharmacology: Sumatriptan has been shown to be effective in relieving migraine headache. It is an agonist for a vascular 5-hydroxytryptamine1D (5-HT1D) receptor subtype (a member of the 5-HT1 family), and has only weak affinity for 5-HT1A receptors and no significant activity (as measured using standard radioligand binding assays) or pharmacological activity at 5-HT2, 5-HT3, 5-HT4,…

IFEX® Bristol Ifosfamide Antineoplastic Agent Caution: Ifosfamide is a potent drug and should be used only by physicians experienced with cancer chemotherapeutic drugs (see Warnings and Precautions). In those patients who develop bacterial, fungal or viral infections, interruption or modification of dosage should be considered. Blood counts should be taken at regular intervals. Due to the urotoxic effect of oxazaphosphorines, ifosfamide should not be administered without the use of a…

HYSKON® Medisan Pharmaceuticals Dextran 70 (32% w/v) in Dextrose Hysteroscopy Fluid Indications And Clinical Uses: For use with the hysteroscope as an aid in distending the uterine cavity and in irrigating and visualizing its surfaces. Contra-Indications: Hypersensitivity to dextran. Contraindications relative to the hysteroscopic procedure itself (e.g., pregnancy, endometrial carcinoma). Precautions: When large amounts of Hyskon are employed for hysteroscopy, the possible occurrence of systemic adverse effects including plasma volume…

HYPERSTAT® I.V. INJECTION Schering Diazoxide Antihypertensive Action And Clinical Pharmacology: Diazoxide injection produces a prompt reduction in blood pressure by relaxing smooth muscle in the peripheral arterioles. Cardiac output is increased as blood pressure is reduced by diazoxide; coronary and cerebral blood flow are maintained. Renal blood flow is increased after an initial decrease. Diazoxide has no known direct action on the CNS. Patients refractory to other antihypertensive agents usually…

HYDREA® Squibb Hydroxyurea Antineoplastic Agent Action And Clinical Pharmacology: Neoplastic Disease. The precise mechanism by which hydroxyurea produces its antineoplastic effects cannot, at present, be described. However, the reports of various studies in rat and human tissue cultures lend support to the hypothesis that hydroxyurea causes an immediate inhibition of DNA synthesis, by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or of protein….

HIBIDIL® 1:2000 Zeneca Chlorhexidine Gluconate Antiseptic Action And Clinical Pharmacology: Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have been found in man following oral…