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BUTISOL® SODIUM Carter Horner Butabarbital Sodium Sedative – Hypnotic Indications And Clinical Uses: A daytime sedative when mild sedation is required for relief of symptoms of anxiety or tension resulting from emotional, physical, or situational stress. May be used in such conditions as: neuroses and anxiety-tension states, functional gastrointestinal disorders, peptic ulcer, menopausal syndrome, premenstrual tension, hyperthyroidism, essential hypertension, coronary artery disease, congestive heart failure, preoperative apprehension and insomnia. Contra-Indications:…

BRICANYL® Tablets BRICANYL® TURBUHALER® Astra Terbutaline Sulfate Bronchodilator Action And Clinical Pharmacology: Terbutaline produces bronchodilation by stimulation of the B2 adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of muscle fibres. This action is manifested by an increase in pulmonary function as demonstrated by FEV1 measurements. Terbutaline also produces a decrease in airway and pulmonary resistance. Following inhalation of terbutaline Turbuhaler, a significant improvement in pulmonary function measurements is…

BRONALIDE® Boehringer Ingelheim Flunisolide Corticosteroid Aerosol Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and anti-allergic activity in classical test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. When inhaled at therapeutic doses it has potent anti-inflammatory activity locally on the bronchial mucosa. Following i.v. administration in man of 2 mg flunisolide, plasma concentrations of 12 to…

BRETYLATE® Glaxo Wellcome Bretylium Tosylate Antiarrhythmic Action And Clinical Pharmacology: Bretylium is an adrenergic-neurone blocking agent. The mechanism by which it exerts its antiarrhythmic action is not fully understood. Although evidence has indicated that the benefit of bretylium in abating tachyarrhythmias may be due to its antiadrenergic properties, this has still not been firmly established. Some reports have even indicated that there is a clear-cut dissociation between the neuron-blocking and…

BREVIBLOC® Zeneca Esmolol HCl Beta-adrenergic Receptor Blocking Agent Action And Clinical Pharmacology: Esmolol is a beta-adrenergic receptor blocking agent with predominant blocking effect on beta-1 receptors. It does not possess significant intrinsic sympathomimetic or membrane stabilizing activity. Esmolol, which is administered only i.v., has a rapid onset and a short duration of action. Pharmacodynamics: In human electrophysiology studies, esmolol produced effects typical of a beta-blocker: a decrease in the heart…

BLOCADREN® Frosst Timolol Maleate Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Timolol is a beta-adrenergic receptor blocking agent. The mechanism of the antihypertensive effect of beta- adrenergic receptor blocking agents has not yet been established. Among the factors that may be involved are: competitive ability to antagonize catecholamine-induced tachycardia at the beta receptor sites in the heart, thus decreasing cardiac output; inhibition of renin release by the kidneys; inhibition…

BONAMINE™ Pfizer Meclizine HCl Antiemetic Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine structures may be the site of action. Indications And Clinical Uses: For prophylaxis and symptomatic relief of nausea, vomiting and vertigo associated with motion…

BONEFOS® Rh´ne-Poulenc Rorer Clodronate Disodium Bone Metabolism Regulator – Antihypercalcemic Agent Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which bind to hydroxyapatite and inhibit formation and dissolution of calcium crystals in vitro. Bisphosphonates including clodronate act on the bony skeleton causing reduction of normal and abnormal bone resorption. Clodronate alters the activities of osteoclasts and osteoblasts and the balance of bone resorption and bone formation is…

BLEOMYCIN SULFATE USP Faulding Antineoplastic Action And Clinical Pharmacology: Experiments with isolated DNA have shown that bleomycin binds to the DNA molecule and cleaves it. This results in the inhibition of DNA synthesis. There is also evidence of lesser inhibition of RNA and protein synthesis. Bleomycin exhibits a wide spectrum of in vitro and in vivo activity. It demonstrates inhibition of DNA synthesis in E. coli, B. subtilis, Ehrlich ascites…

BIOLON™ Ophtapharma Sodium Hyaluronate Ophthalmosurgical Aid Action And Clinical Pharmacology: Sodium hyaluronate is a physiological material found in both animal and human tissues. It is a polysaccharide consisting of a repeating disaccharide of N-acetylglucosamine and sodium glucuronate, linked by alternating b-1,3 and b-1,4 glycosidic bonds. Chemically identical in all species, hyaluronate can be found in the vitreous and aqueous humor of the eye, in synovial fluid, in skin and in…