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CYCLOMEN® Sanofi Danazol Pituitary Gonadotropin Inhibitor Action And Clinical Pharmacology: In women of reproductive age, the primary mode of action of danazol is believed to be by suppression of the pituitary-ovarian axis, and inhibition of the output of gonadotropins from the pituitary-gland. Other mechanisms of action currently postulated to explain its effects are: inhibition of midcycle FSH and LH surges: inhibition of enzymes required for gonadal hormone synthesis: competitive binding…

  CYCLOPENTOLATE HCl General Monograph, Cycloplegic – Mydriatic – Anticholinergic Cyclopentolate is an anticholinergic agent that induces relaxation of the sphincter of the iris and the ciliary muscles. When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 to 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration…

CUPRIMINE® MSD Penicillamine Chelating Agent Action And Clinical Pharmacology: As a chelating agent, penicillamine removes copper and lead from the body. In copper chelation, from in vitro studies which indicate that one atom of copper combines with 2 molecules of penicillamine. It would appear that 1 g of penicillamine should be followed by the excretion of about 200 mg of copper; however, the actual amount excreted is about 1% of…

CYCLOCORT® Stiefel Amcinonide Topical Corticosteroid Indications And Clinical Uses: The relief of inflammatory manifestations of acute and chronic corticosteroid-responsive dermatoses, such as atopic dermatitis, contact and eczematous dermatoses, psoriasis and neurodermatitis. Topical corticosteroid therapy, although responsible for remissions of dermatoses, especially of allergic origin, cannot be expected to prevent recurrence. In the case of contact or allergic dermatitis, it is important to investigate causal factors and to remove the offending…

CYCLEN® Janssen-Ortho Norgestimate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or actual…

CREO-RECTAL® Nadeau Diphenylpyraline HCl – Camphor – Guaiacol Expectorant – Antihistaminic Indications And Clinical Uses: For the temporary relief of coughs due to colds, bronchitis, bronchial asthma. Contra-Indications: Hypersensitivity to any of the components. Precautions: Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or other drugs with CNS…

CREON® 10 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea, post-pancreatectomy, post-gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Perianal irritation, and rarely, inflammation, could occur…

CREON® 25 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea and postpancreatectomy, post gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Pregnancy and Lactation: There is…

COSMEGEN® MSD Dactinomycin Antineoplastic Action And Clinical Pharmacology: Dactinomycin is an antibiotic obtained as the principal component of the mixture of actinomycins produced by S. parvullus. This organism, unlike other species, yields an essentially pure substance that contains only traces of similar compounds differing in the amino acid content of the peptide side chains. It is available for clinical use as a sterile, yellow lyophilized powder which, in aqueous solution,…

CORTROSYN® Organon Cosyntropin Adrenocorticotropic Hormone Action And Clinical Pharmacology: The pharmacologic profile of cosyntropin is similar to that of purified natural ACTH, it has been established that 250 µg of cosyntropin will stimulate the adrenal cortex maximally and to the same extent as 25 units of natural ACTH. These clinical observations confirm earlier animal and assay studies establishing the 1:100 ratio. This dose of cosyntropin will produce maximal secretion of…