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DEPO-TESTOSTERONE CYPIONATE Pharmacia & Upjohn Testosterone Cypionate Androgen Action And Clinical Pharmacology: Qualitatively similar to testosterone and its esters in physiologic activity, testosterone cypionate has the advantage of prolonged effect. In hypogonadal males, the effect of a single injection of 200 to 400 mg of testosterone cypionate, was observed to be maintained for 2 to 4 weeks, which is 2 to 4 times longer than the effect produced by a…

DEMULEN® 30 DEMULEN® 50 Searle Ethynodiol Diacetate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Demulen 30: Prevention of pregnancy. Demulen 50:…

DEPEN® Carter Horner Penicillamine Chelating Agent Action And Clinical Pharmacology: As a chelating agent, penicillamine removes copper from the body. In vitro studies indicate that one atom of copper combines with 2 molecules of penicillamine. It would appear that 1 g of penicillamine should be followed by the excretion of about 200 mg of copper; however, the actual amount excreted is about 1% of this. Penicillamine also reduces excess cystine…

DEPAKENE® Abbott Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Although valproic acid’s mechanism of action has not yet been established, the drug’s anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect on the neuronal membrane is unknown. Valproic acid is rapidly absorbed after oral administration. Peak serum levels occur approximately 1 to 4 hours after a single oral dose. The serum half-life of valproic…

DELTASONE® Pharmacia & Upjohn Prednisone Corticosteroid Action And Clinical Pharmacology: Prednisone is a corticosteroid, which like other steroids, acts by controlling the rate of synthesis of proteins. The corticosteroids react with receptor proteins in the cytoplasm of sensitive cells to form a steroid-receptor complex. The steroid receptor complex moves into the nucleus where it binds to chromatin. Information carried by the steroid or more likely by the receptor protein directs…

DEMEROL® Sanofi Meperidine HCl Analgesic Action And Clinical Pharmacology: Meperidine is an opioid analgesic which acts predominantly as a mu-agonist. In its effects on the CNS, meperidine resembles but is not identical to morphine. Analgesic effects are detectable within about 15 minutes following oral administration, reaching a peak within about 2 hours and subsiding gradually over several hours thereafter. Onset of analgesic effect is faster (within 10 minutes) after s.c….

DECLOMYCIN® Wyeth-Ayerst Demeclocycline HCl Antibiotic Indications And Clinical Uses: Many strains of bacteria have been shown to be resistant to the tetracyclines. These include certain strains of streptococci, staphylococci, pneumococci, gonococci, and many other gram-negative organisms. Therefore, culture and sensitivity testing are advised to determine the susceptibility of the infecting organisms to tetracyclines. Chemotherapy should not be initiated until all the necessary bacteriological investigations have been started. Microorganisms that have…

DECA-DURABOLIN® Organon Nandrolone Decanoate Androgenic – Anabolic Steroid Indications And Clinical Uses: As adjunctive therapy in senile and postmenopausal osteoporosis. Anabolic steroids are without value as primary therapy but may be of value in adjunctive therapy. Equal or greater consideration should be given to diet, calcium balance, physiotherapy and good general health promoting measures, in pituitary dwarfism anabolic agents may be used with care until growth hormone is more available….

DELATESTRYL® Squibb Testosterone Enanthate Androgen Indications And Clinical Uses: Androgen therapy in the male (eunuchism, eunuchoidism, impotence of glandular origin, cryptorchidism, climacteric, senile pruritus), and in the female (menorrhagia, frigidity, palliation of premenopausal mammary carcinoma, inhibition of lactation, postpartum breast engorgement, menopausal syndrome), and in males and females (delayed bone healing, spinal paraplegia, senile osteoporosis, dystrophy, cachexia due to wasting illness). Contra-Indications: Androgens are contraindicated in male patients with prostatic…

DELESTROGEN® Squibb Estradiol Valerate Estrogen Indications And Clinical Uses: In nonpregnant women, Delestrogen is indicated in the treatment of amenorrhea (primary and secondary); disturbances of the menstrual cycle (hypomenorrhea, oligomenorrhea, irregular cycles, metrorrhagia); deficiency syndromes (castration, primary ovarian failure, menopause); local manifestations of estrogen deficiency (senile vaginitis, pruritus vulvae); abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology; and for the production of secretory endometrium and…