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DIAMICRON® Servier Gliclazide Oral Hypoglycemic Action And Clinical Pharmacology: Gliclazide is an hypoglycemic agent of the sulfonylurea group. Its hypoglycemic action is related to an improvement in insulin secretion from the functioning beta cells of the pancreas. It potentiates the insulin release and improves the dynamics of insulin. Hemobiological properties of gliclazide have been observed in pharmacology studies. These are attributed to gliclazide action on the platelet behavior, prostaglandin equilibrium…

DIANE®-35 Berlex Canada Cyproterone Acetate – Ethinyl Estradiol Acne Therapy Action And Clinical Pharmacology: Diane-35 is a combination antiandrogen-estrogen for use in the treatment of androgen-dependent dermatological conditions in females. Cyproterone is a steroid compound with potent antiandrogenic, progestogenic and antigonadotrophic activity. It exerts its antiandrogenic effect by blocking androgen receptors. It also reduces androgen synthesis by a negative feedback effect on the hypothalamo-pituitary-ovarian systems. The estrogen component (ethinyl estradiol)…

DIAZEMULS® Pharmacia & Upjohn Diazepam Injectable Emulsion Anxiolytic – Sedative Action And Clinical Pharmacology: Diazemuls is an injectable emulsion of diazepam, a drug with known anxiolytic-sedative and muscle relaxant properties. Diazepam has been found useful for short-term symptomatic relief of excessive anxiety and tension in patients with anxiety neurosis, although anxiety and tension associated with the stresses of everyday life usually do not require treatment with anxiolytic drugs. Diazepam must…

DESYREL® DESYREL® DIVIDOSE Bristol Trazodone HCl Antidepressant Action And Clinical Pharmacology: Trazodone is a psychoactive compound with sedative and antidepressant properties. Its mechanism of action in humans is not clear. Trazodone is well absorbed after oral administration with peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food. The mean plasma elimination half-life is 4.4 hours for the period from 3…

DIABINESE™ Pfizer Chlorpropamide Oral Hypoglycemic Action And Clinical Pharmacology: Chlorpropamide is an orally active hypoglycemic agent which reduces blood sugar concentration without affecting glucose tolerance. It probably acts by stimulating insulin secretion in the presence of functioning pancreatic islet tissue. Chlorpropamide is absorbed readily from the gastrointestinal tract and is bound to plasma proteins. Within 1 hour after a single oral dose, it is detectable in the blood, and the…

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

DESOCORT® Galderma Desonide Topical Corticosteroid Action And Clinical Pharmacology: Desonide, like all topical corticosteroids, exhibits anti-inflammatory, antipruritic and vasoconstrictive actions. tag_IndicationsIndications Indications And Clinical Uses: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Hypersensitivity to any of the components. Not for ophthalmic use. Precautions: General: Systemic absorption of topical corticosteroids…

DERMOVATE® Glaxo Wellcome Clobetasol 17-Propionate Topical Corticosteroid Action And Clinical Pharmacology: The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic…

DEPO-MEDROL® Pharmacia & Upjohn Methylprednisolone Acetate Glucocorticoid Action And Clinical Pharmacology: Depo-Medrol is a sterile aqueous suspension of the synthetic glucocorticoid methylprednisolone acetate. It has a strong and prolonged anti-inflammatory, immunosuppressive and antiallergic activity. Depo-Medrol can be administered i.m. for a prolonged systemic activity as well as in situ for a local treatment. The prolonged activity of Depo-Medrol is explained by the slow release of the active substance. Indications And…

DEPO-MEDROL® with Lidocaine Pharmacia & Upjohn Methylprednisolone Acetate – Lidocaine HCl Glucocorticoid with Local Anesthetic Action And Clinical Pharmacology: Methylprednisolone is an anti-inflammatory steroid. Estimates of the relative potencies of methylprednisolone and prednisolone range from 1.13 to 2.1 with an average of 1.5. In general the required daily dose of methylprednisolone can be estimated to be two-thirds (or 0.7) the required daily dose of prednisolone. While the effect of parenterally…