You searched for : 'X'

DDAVP® Spray and Rhinyle Nasal Solutions Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Approximately 10 to…

DECADRON® Phosphate Injection MSD Dexamethasone Sodium Phosphate Corticosteroid Indications And Clinical Uses: By i.v. or i.m. injection when oral therapy is not feasible: Adrenocortical Insufficiency: Dexamethasone sodium phosphate injection has predominantly glucocorticoid activity with low mineralocorticoid activity. Therefore, it does not offer complete replacement therapy, and its use must be supplemented with salt and/or desoxycorticosterone. When so supplemented, dexamethasone sodium phosphate injection is indicated in the impairment of all adrenocortical…

DDAVP® INJECTION Ferring Desmopressin Acetate Antidiuretic Hormone Analogue Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the natural human hormone, arginine vasopressin. As such, it exerts its action on the reabsorption of water in the renal tubule. It also causes a transient increase in all components of the Factor VIII complex and plasminogen activator. These are released very rapidly from their endothelial cell storage sites. Moreover, it…

DALMANE® Roche Flurazepam HCl Hypnotic Action And Clinical Pharmacology: Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Flurazepam decreases sleep latency and number of awakenings for a consequent increase in total sleep time. The duration of hypnotic effect and the profile of unwanted effects may be influenced by the alpha (distribution) and beta (elimination) half-lives…

DANTRIUM® CAPSULES Procter & Gamble Pharmaceuticals Dantrolene Sodium Skeletal Muscle Relaxant Action And Clinical Pharmacology: Recordings of muscle tensions and electrical activity in both animal and man suggest that dantrolene has a direct inhibitory effect on the development of contractile tension. Spastic patients receiving dantrolene have shown a 40 to 70% reduction in the skeletal muscle tension induced by direct electrical stimulation of the motor nerve with no alteration of…

DANTRIUM® INTRAVENOUS Procter & Gamble Pharmaceuticals Dantrolene Sodium Management of Malignant Hyperthermia Action And Clinical Pharmacology: Dantrolene is a muscle relaxant acting specifically on skeletal muscles. In isolated muscle preparations, dantrolene uncouples the excitation and contraction of skeletal muscles, probably by interfering with the release of calcium from the sarcoplasmic reticulum. In the anesthetic induced malignant hyperthermia syndrome, evidence points to a predisposing intrinsic abnormality of muscle tissue. In affected…

DARAPRIM® Glaxo Wellcome Pyrimethamine Antimalarial Action And Clinical Pharmacology: Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine does not destroy gametocytes, but arrests sporogony in the mosquito. Peak plasma levels are found between 2 and 4 hours…

DALACIN® C Pharmacia & Upjohn Clindamycin HCl Antibiotic Action And Clinical Pharmacology: Clindamycin exerts its antibacterial effect by causing cessation of protein synthesis and also causing a reduction in the rate of synthesis of nucleic acids. In vitro studies indicate that clindamycin has antibacterial activity against sensitive gram-positive organisms. The spectrum of activity includes staphylococci (including penicillinase-producing and methicillin resistant strains), hemolytic streptococci, S. viridans and S. pneumoniae. In addition,…

DALACIN® C PHOSPHATE STERILE SOLUTION Pharmacia & Upjohn Clindamycin Phosphate Antibiotic Action And Clinical Pharmacology: Following parenteral administration, biologically inactive clindamycin phosphate is rapidly hydrolyzed in plasma to active clindamycin. Clindamycin exerts its antibacterial effect by binding to the 50 S ribosomal subunit of susceptible bacteria, causing a reduction in the rate of synthesis of nucleic acid, and cessation of protein synthesis. Clindamycin is primarily bacteriostatic, but may be bactericidal…

DALACIN® T TOPICAL SOLUTION Pharmacia & Upjohn Clindamycin Phosphate Antibiotic Action And Clinical Pharmacology: Clindamycin phosphate is inactive in vitro but in vivo hydrolysis converts this compound to the antibacterially active clindamycin. Clindamycin has been shown to have in vitro activity against isolates of P. acnes which may account for its usefulness in acne. Clindamycin activity has been demonstrated in serum, urine and in comedonal extracts from acne patients. The…