Depo-Testosterone (Testosterone Cypionate Injection)


Pharmacia & Upjohn

Testosterone Cypionate


Action And Clinical Pharmacology: Qualitatively similar to testosterone and its esters in physiologic activity, testosterone cypionate has the advantage of prolonged effect. In hypogonadal males, the effect of a single injection of 200 to 400 mg of testosterone cypionate, was observed to be maintained for 2 to 4 weeks, which is 2 to 4 times longer than the effect produced by a comparable dose of testosterone propionate

Indications And Clinical Uses: Male: Eunuchism, eunuchoidism, deficiency after castration. Male climacteric symptoms when these are secondary to androgen deficiency. Oligospermia.

Male or Female: Postmenopausal or senile osteoporosis. Androgens are without value as primary therapy, but may be of value as adjunctive therapy. Equal or greater consideration should be given to diet, calcium balance, physiotherapy, and good general health-promoting measures.

Contra-Indications: In patients with prostatic carcinoma, severe cardiorenal disease and severe persistent hypercalcemia.

Pregnancy: Since it may cause masculinization of the female fetus, testosterone cypionate is also contraindicated during pregnancy.

Precautions: Since androgens, in general, tend to promote retention of sodium and water, patients receiving testosterone cypionate – in particular, elderly patients – should be observed for edema. Hypercalcemia may occur, particularly in immobilized patients; use of testosterone cypionate should be discontinued as soon as hypercalcemia is detected.

Adverse Reactions: In the male, excessive doses or prolonged administration of testosterone cypionate may cause inhibition of testicular function resultant oligospermia and decreased ejaculation volume. Gynecomastia has been reported in males treated with testosterone, but this complication usually disappears upon cessation of therapy. In young boys, androgens should be used with caution to avoid precocious sexual development and premature epiphyseal closure.

In the female, large doses of testosterone cypionate may produce masculinization with signs such as hirsutism, deepening of the voice, enlargement of the clitoris, acne, increased libido and menstrual irregularities. WIth the exception of the voice change, these effects tend to disappear following cessation of therapy.

Dosage And Administration: Sterile solution of testosterone cypionate is for i.m. use only. Dosage will vary depending upon the individual, the condition being treated, its severity, and prior androgen therapy. Because of the protracted action of testosterone cypionate, injections more frequently than every 2 weeks are seldom required.

Eunuchism, Eunuchoidism: For complete replacement in eunuchs and eunuchoid patients, the usual dose is 200 to 400 mg injected at intervals of 3 to 4 weeks. It is usually preferable to begin treatment with full therapeutic doses, which are later adjusted to individual requirements. Priapism is a sign of excessive dosage and is an indication for temporary withdrawal of androgen therapy.

Impotence due to Testicular Deficiency, Male Climacteric. Testosterone cypionate may be given every 3 to 4 weeks in doses ranging from 200 to 400 mg.

Oligospermia: To stimulate spermatogenesis when trial androgen therapy is indicated in subfertile males with oligospermia, recommended dosage is: (1) 100 to 200 mg every 3 to 6 weeks for development and maintenance of testicular function: or (2) 200 mg each week for 6 to 10 weeks for suppression which may then be followed by rebound spermatogenesis following discontinuance of the injection.

Anabolic Effect, Osteoporosis: The dosage for anabolic effect should be adjusted according to age, sex, and the condition of the individual patient. In the majority of cases, the dose will range from 200 to 400 mg injected every 3 to 4 weeks. In addition, an adequate diet should be provided and prolonged immobilization avoided whenever possible.

Availability And Storage: Each mL contains: testosterone cypionate 100 mg. Nonmedicinal ingredients: benzyl alcohol and benzyl benzoate in cottonseed oil. Vials of 10 mL.

Store at room temperature. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.

DEPO-TESTOSTERONE CYPIONATE Pharmacia & Upjohn Testosterone Cypionate Androgen

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