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NOVOCAIN® Sanofi Procaine HCl Local Anesthetic Action And Clinical Pharmacology: Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibres….

NOVASOURCE™ RENAL Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete, calorically dense, moderate protein formula with a vitamin/mineral profile designed for dialysis patients with acute and chronic renal failure. Appropriate for both oral and tube feeding use. Precautions: Not for parenteral administration. Dosage And Administration: 1 000 mL or 8 360 kJ (4.2 Tetra Brik Paks or 2 000 kcal) provides at least 100% of the Canadian…

NORVASC™ Pfizer Amlodipine Besylate Antihypertensive – Antianginal Action And Clinical Pharmacology: Amlodipine is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). Amlodipine is a member of the dihydropyridine class of calcium antagonists. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscle and…

NORPRAMIN® Hoechst Marion Roussel Desipramine HCl Antidepressant Action And Clinical Pharmacology: Desipramine displays an antidepressant property similar to that of other tricyclic antidepressants. It is the active “in vivo” metabolite of imipramine and as such, shares many of imipramine’s pharmacologic effects. The anticholinergic actions of desipramine are responsible for many of the commonly observed side effects of the drug. Desipramine causes ECG changes such as prolongation of the P-R interval…

NOVA-T Berlex Canada Intrauterine Copper Intrauterine Contraceptive Description: Nova-T is an intrauterine device made of plastic (polyethylene) approximately in the shape of a T. Polyethylene threads are attached to the lower portion. The horizontal and vertical arms of the T are 32 mm in length and 1.2 mm in diameter; a loop 2.6 mm wide is found at the tip of the vertical arm; and a thin copper wire (107-141…

NORMACOL® Rivex Pharma Sterculia Bulk Laxative Indications And Clinical Uses: Sterculia is used as a bulk laxative, since by taking up moisture it increases the volume of the feces and promotes peristalsis. Ten mL of sterculia provide dietary bulk equivalent to 2 kg of fresh vegetables. It provides gentle relief of occasional constipation. Produces bowel movement in 12 to 72 hours. Precautions: As with all hygroscopic laxatives, it is important…

NORPLANT® Wyeth-Ayerst Levonorgestrel Contraceptive Implant Action And Clinical Pharmacology: Norplant consists of levonorgestrel implants, a set of 6 flexible closed capsules made of Silastic (dimethylsiloxane/methylvinylsiloxane copolymer) each containing 36 mg of the progestin levonorgestrel. Levonorgestrel, 18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(17a)-(-)-, is a totally synthetic and biologically-active progestin which exhibits no significant estrogenic activity and is highly progestational. The absolute configuration conforms to that of D-natural steroids. Levonorgestrel is not subjected to a “first-pass” effect…

NORGESIC™ NORGESIC™ FORTE 3M Pharmaceuticals Orphenadrine Citrate – ASA – Caffeine Analgesic – Skeletal Muscle Relaxant Indications And Clinical Uses: Symptomatic relief of mild to moderate pain. Contraindications, Precautions and Adverse Effects: See Norflex and ASA. Do not exceed the recommended dose without consulting a physician. Reye’s Syndrome may develop in individuals who have chickenpox, influenza, or flu symptoms. Some studies suggest a possible association between the development of Reye’s…

NORINYL® 1/50 Searle Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic…

NORITATE® Dermik Laboratories Canada Metronidazole Antirosacea Agent Action And Clinical Pharmacology: Metronidazole topical cream is particularly effective against the inflammatory papulopustular component of rosacea. The mechanisms by which metronidazole act in reducing inflammatory lesions of rosacea are unknown, but may include an antibacterial and/or an anti-inflammatory effect. Indications And Clinical Uses: For topical application in the treatment of inflammatory papules, pustules and erythema of rosacea. Contra-Indications: In individuals with a…