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NORLUTATE® Parke-Davis Norethindrone Acetate Progestational Agent Action And Clinical Pharmacology: Norethindrone acetate differs from norethindrone only in potency; the acetate is approximately twice as potent. Transforms proliferative endometrium into secretory endometrium. Inhibits (at the usual dose range) the secretion of pituitary gonadotropins, which in turn prevents follicular maturation and ovulation. May also demonstrate some estrogenic, anabolic or androgenic activity but should not be relied upon. Indications And Clinical Uses: Amenorrhea;…

NORCURON® Organon Vecuronium Bromide Nondepolarizing Neuromuscular Blocking Agent Action And Clinical Pharmacology: Vecuronium is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic curariform pharmacological actions of this class of drugs. It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited and neuromuscular block is reversed by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine. Vecuronium is about a third more potent…

NIZORAL® Shampoo McNeil Consumer Products Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and…

NIZORAL® Tablets Janssen-Ortho Ketoconazole Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma membrane….

NIZORAL® Cream Janssen-Ortho Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma…

NITROLINGUAL® PUMPSPRAY Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely, relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demand rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation…

NITRONG® SR Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of Nitrong (nitroglycerin) is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NITROSTAT™ Parke-Davis Nitroglycerin Coronary Vasodilator Indications And Clinical Uses: For the prophylaxis, treatment and management of patients with angina pectoris. Contra-Indications: In patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to nitroglycerin. Manufacturers’ Warnings In Clinical States: The use of nitroglycerin during the early course of acute myocardial infarction requires particular attention to hemodynamic monitoring and clinical status because of the possibility…

NITRO-DUR® Key Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance and…

NITROGLYCERIN General Monograph, CPhA Glyceryl Trinitrate Antianginal – Antihypertensive Pharmacology: Nitroglycerin, in common with other nitrates, produces generalized vasodilation, thereby decreasing venous return and workload on the heart. Both arterial and venous dilation occur, although venous effects predominate. Coronary vasodilation also occurs even in the presence of atherosclerosis. Relaxation of vascular smooth muscle is a result of stimulation of cyclic guanosine monophosphate (GMP) production as well as inhibition of thromboxane…