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COLY-MYCIN® M PARENTERAL Parke-Davis Sodium Colistimethate Antibiotic Action And Clinical Pharmacology: Sodium colistimethate is the pentasodium salt of the penta (methanesulfonic acid) derivative of colistin. Colistin is a basic polypeptide antibiotic substance produced by the growth of Bacillus polymyxa var. colistinus. Colistin derivatives appear to alter the permeability of the bacterial cytoplasmic membrane, causing leakage of intracellular nucleosides. The drugs are bactericidal in action. I.M. administration of sodium colistimethate with…

COMBIVENT® Inhalation Aerosol Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the b2-adrenergic bronchodilator, salbutamol sulfate. Each actuation from the valve delivers 20 µg ipratropium bromide and 120 µg salbutamol sulfate (equivalent to 100 µg salbutamol base). Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic with bronchodilator properties….

COLACE® Roberts Docusate Sodium Stool Softener Indications And Clinical Uses: The management of constipation due to hard stools, in painful anorectal conditions, in cardiac and other conditions in which maximum ease of passage is desirable to avoid difficult or painful defecation, and when peristaltic stimulants are contraindicated. Contra-Indications: Presence of abdominal pain, nausea or vomiting. Precautions: Do not administer concomitantly with mineral oil: increased absorption of the oil may result….

CoACTIFED® Preparations Glaxo Wellcome Triprolidine HCl – Codeine Phosphate – Pseudoephedrine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: CoActifed Expectorant: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum. CoActifed Syrup and Tablets: The treatment of cough associated with inflamed mucosa. Contra-Indications: This drug should not be used in newborn or premature infants. Hypersensitivity to codeine phosphate or other narcotics, triprolidine hydrochloride, or…

CODEINE CONTIN® Purdue Frederick Codeine Monohydrate – Codeine Sulfate Trihydrate Opioid Analgesic Action And Clinical Pharmacology: Codeine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, codeine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and…

CLOPIXOL® CLOPIXOL-ACUPHASE® CLOPIXOL® DEPOT Lundbeck Zuclopenthixol Dihydrochloride Zuclopenthixol Acetate Zuclopenthixol Decanoate Antipsychotic Action And Clinical Pharmacology: Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors. Zuclopenthixol also has high affinity for a1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and a2-adrenergic receptors. Pharmacokinetics: The pharmacokinetics of zuclopenthixol appear to be linear over…

CLAVULIN® SmithKline Beecham Amoxicillin – Clavulanate Potassium Antibiotic – b-Lactamase Inhibitor Action And Clinical Pharmacology: Amoxicillin exerts a bactericidal action against sensitive organisms during the stage of active multiplication through the inhibition of the biosynthesis of bacterial cell wall mucopeptides. Clavulanic acid inhibits specific b-lactamases of some microorganisms and allows amoxicillin to inhibit amoxicillin (ampicillin) resistant organisms which produce clavulanic acid sensitive b-lactamases. Indications And Clinical Uses: For the treatment…

CLARITIN® EXTRA Schering Loratadine – Pseudoephedrine Sulfate Histamine H1-Receptor Antagonist – Sympathomimetic Amine Action And Clinical Pharmacology: Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at 2 hours and persists throughout the 24 hour observation period. Single oral doses up to 160 mg…

CITRO-MAG® Rougier Magnesium Citrate Laxative Indications And Clinical Uses: A laxative or purgative. Preparation of the colon for x-ray examination. Contra-Indications: Abdominal pain, nausea or vomiting. Known or suspected intestinal obstruction. Precautions: Frequent or prolonged use may result in dependence on laxatives. Dosage: Adults: as a laxative: 1/4 to 1/2 bottle; as a purgative: 1 bottle before breakfast or as prescribed before x-ray examination. Children (6 to 12 years): 30…

CHOLOXIN® Knoll hyper Hypolipidemic Thyroactive Agent Action And Clinical Pharmacology: Dextrothyroxine reduces serum cholesterol levels in hyperlipidemic patients. Beta lipoprotein and triglyceride fractions may also be reduced from previously elevated levels. Dextrothyroxine stimulates the liver to increase catabolism and excretion of cholesterol and its degradation products via the biliary route into the feces. Cholesterol synthesis is not inhibited and abnormal metabolic end-products do not accumulate in the blood. Indications And…