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CHOLECYSTOKININ Ferring Diagnostic Cholecystokinetic Action And Clinical Pharmacology: Cholecystokinin (CCK) is a natural polypeptide, formed in the APUD cells of the proximal mucosa of the small intestine. It stimulates secretion of pancreatic digestive enzymes, the flow of bile and the secretion from the glands of Brunner. It stimulates contraction of the gallbladder, inhibits contraction of the lower esophageal sphincter and the sphincter of Oddi and increases motility of the stomach…

CHOLEDYL® EXPECTORANT Parke-Davis Oxtriphylline – Guaifenesin Bronchodilator – Expectorant Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. tag_IndicationsIndications Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with chronic obstructive pulmonary emphysema, bronchial asthma, chronic bronchitis and related bronchospastic disorders and where expectoration is required. Precautions: Patients starting therapy should be carefully observed to determine if this fixed dose combination is…

CHLOR-TRIPOLON N.D.® Schering Loratadine – Pseudoephedrine Sulfate Histamine H1-Receptor Antagonist – Sympathomimetic Amine Action And Clinical Pharmacology: Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at 2 hours and persists throughout the 24 hour observation period. Single oral doses up to 160 mg…

CERUMOL® Solvay Pharma Paradichlorobenzene – Chlorbutol – Oil of terebinth Cerumenolytic Indications And Clinical Uses: Removal of cerumen from the external auditory meatus. Contra-Indications: Perforated ear drum, otitis externa, seborrheic dermatitis or eczema affecting the external ear. Hypersensitivity to any of the components. Precautions: Cerumol contains peanut oil, and although there have been no reports of any reaction, patients allergic to peanuts should use Cerumol only under the advice of…

CHERACOL® Roberts Codeine Phosphate – Guaifenesin – Ammonium Chloride Antitussive – Expectorant Indications And Clinical Uses: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contraindications Contraindications and Precautions: In patients with asthma or pulmonary emphysema, indiscriminate use may precipitate respiratory insufficiency resulting from increased viscosity of bronchial secretions and suppression of the cough reflex. Use with…

CEREBYX® Parke-Davis Fosphenytoin Sodium Antiepileptic Action And Clinical Pharmacology: Introduction: Following parenteral administration of fosphenytoin, fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, 1 mmol of phenytoin is produced. The pharmacological and toxicological effects of fosphenytoin include those of phenytoin. However, the hydrolysis of fosphenytoin to phenytoin yields 2 metabolites, phosphate and formaldehyde. Formaldehyde is subsequently converted to formate, which is in turn metabolized via…

CERUBIDINE® Rh´ne-Poulenc Rorer Daunorubicin Antimitotic – Antibiotic Action And Clinical Pharmacology: Daunorubicin inhibits the synthesis of nucleic acids; its effect on desoxyribonucleic acid is particularly rapid and marked. Ribonucleic acid is more gradually affected. It appears that the action of the drug is the result of the formation of a complex with desoxyribonucleic acid in the cell nucleus; this blocks the site of action of the polymerases and gives daunorubicin…

CERUMENEX® Purdue Frederick Triethanolamine Polypeptide Oleate-condensate Cerumenolytic Indications And Clinical Uses: For removal of impacted cerumen. Cleansing prior to aural examination, treatment, or audiometry. Should not be used for routine wax removal or cleaning of the ears. Contra-Indications: Perforated eardrum. Middle ear infection or severe inflammatory or atopic dermatitis in the external ear. Positive patch test. History of untoward reaction to Cerumenex. Precautions: Should be used with extreme caution in…

CELESTONE® SOLUSPAN ® Schering Betamethasone Sodium Phosphate – Betamethasone Acetate Injectable Glucocorticoid Indications And Clinical Uses: (1) I.M. injection in allergic, dermatologic, rheumatic, and other conditions responsive to systemic corticosteroids, including bursitis; (2) injection directly into the affected tissues in bursitis and associated inflammatory disorders of tendons such as tenosynovitis, and inflammatory disorders of muscle such as fibrositis and myositis; (3) intra-articular and periarticular injection in rheumatoid arthritis and osteoarthritis;…

CELONTIN® Parke-Davis Methsuximide Anticonvulsant Action And Clinical Pharmacology: Methsuximide elevates seizure threshold in the cortex and basal ganglia and reduces synaptic response to low frequency repetitive stimulation. The peroxisomal spike and wave pattern of the EEG, common in petit mal seizure, is suppressed. Pharmacokinetics: Methsuximide is absorbed from the gastrointestinal tract and peak plasma levels are achieved in 1 to 3 hours. The plasma half-life of methsuximide is slightly less…