You searched for : 'U'

CENTRUM® CENTRUM® FORTE CENTRUM® PROTEGRA CENTRUM® SELECT Whitehall-Robins Multiple Vitamins – Minerals Vitamin-Mineral Supplement Indications And Clinical Uses: For use as a nutritional supplement. Contra-Indications: In the presence of hemochromatosis, hemosiderosis, hemolytic anemia. Precautions: Oral iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Oral iron preparations can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption. Adverse Reactions: Rarely, in…

CEFTIN® Glaxo Wellcome Cefuroxime Axetil Antibiotic Action And Clinical Pharmacology: Cefuroxime axetil is an orally active prodrug of cefuroxime. After oral administration, cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release cefuroxime into the blood stream. Conversion to cefuroxime, the microbiologically active form, occurs rapidly. The inherent properties of cefuroxime are unaltered after its administration as cefuroxime…

CEFAZOLIN SODIUM USP Novopharm Antibiotic Action And Clinical Pharmacology: Cefazolin is a cephalosporin antibiotic for parenteral administration. Cefazolin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. Cefazolin is about 85% bound to serum protein. The peak level in serum is approximately 32 to 42 mg/mL after an i.m. injection of 500 mg. Over 80% of injected cefazolin is excreted in the urine during the first 24 hours after…

CeeNU® Bristol Lomustine Antineoplastic Agent Action And Clinical Pharmacology: It is generally agreed that lomustine acts as an alkylating agent but, as with other nitrosoureas, it may also inhibit several key enzymatic processes. Lomustine may be given orally. Following oral administration of radioactive lomustine at doses ranging from 30 mg/mto 100 mg/m about half of the radioactivity given was excreted within 24 hours. The serum half-life of the drug and/or…

CARDURA-1™ CARDURA-2™ CARDURA-4™ Astra Doxazosin Mesylate Antihypertensive Agent – Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH) Action And Clinical Pharmacology: The mechanism of action of doxazosin is selective blockade of alpha1 subtype of post-synaptic, post-junctional alpha-adrenergic receptors. Pharmacodynamics: Hypertension: Administration of doxazosin results in a reduction in systemic vascular resistance. In patients with hypertension there is little change in cardiac output. Maximum reductions in blood pressure usually occur 2 to…

CASODEX® Zeneca Bicalutamide Nonsteroidal Antiandrogen Action And Clinical Pharmacology: Bicalutamide is a nonsteroidal antiandrogen, devoid of other endocrine activity. Bicalutamide competitively inhibits the action of androgens by binding to cytosol androgen receptors in target tissue. This inhibition results in regression of prostatic tumors. Bicalutamide is a racemate and the (R)-enantiomer is primarily responsible for the antiandrogenic activity of bicalutamide. Pharmacokinetics : The absorption, distribution, metabolism and excretion of bicalutamide has…

CARDIOQUIN® Purdue Frederick Quinidine Polygalacturonate Antiarrhythmic Agent Action And Clinical Pharmacology: Quinidine depresses excitability, conduction velocity and contractility of most cardiac tissues by a direct action on cardiac cells. Indirectly, cardiac tissues will also be affected by the anticholinergic and a-adrenoceptor blocking properties of quinidine. According to Vaughan Williams antiarrhythmic drug classification, quinidine is a Class IA agent. Thus, quinidine reduces the maximal rate of phase 0 depolarization, prolongs repolarization…

CARBOLITH™ ICN Lithium Carbonate Antimanic Agent Action And Clinical Pharmacology: Preclinical studies have shown that lithium alters sodium transport in nerve and muscle cells and effects a shift toward intraneuronal metabolism of catecholamines, but the specific biochemical mechanism of lithium action in mania is unknown. Pharmacokinetics: Lithium ions are rapidly absorbed from the gastrointestinal tract and plasma lithium peaks are reached 2 to 4 hours after lithium administration. The distribution…

CARBOPLATIN INJECTION Faulding Antineoplastic Action And Clinical Pharmacology: Carboplatin is a synthetic analogue of cisplatin. Like cisplatin, carboplatin interferes with DNA intrastrand and interstrand crosslinks in cells exposed to the drug. DNA reactivity has been correlated with cytotoxicity. Following administration of carboplatin in man, linear relationships exist between dose and plasma concentrations of total and free ultrafilterable platinum. The area under the plasma concentration versus time curve for total platinum…

CANTHACUR® Pharmascience Cantharidin Vesicant Indications And Clinical Uses: For the topical use of removal of benign epithelial growths such as warts (verruca vulgaris) or molluscum contagiosum. Because of the absence of scarring, cantharidin is useful for treating exposed areas where cosmetic results are important. Painless application and the absence of instruments makes it especially useful for treating children. Contra-Indications: Hypersensitivity to the ingredients. Avoid alcoholic beverages for several hours after…