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Dantrium Capsules (Dantrolene Sodium)

(Pharmaceutical)

DANTRIUM® CAPSULES Procter & Gamble Pharmaceuticals Dantrolene Sodium Skeletal Muscle Relaxant Action And Clinical Pharmacology: Recordings of muscle tensions and electrical activity in both animal and man suggest that dantrolene has a direct inhibitory effect on the development of contractile tension. Spastic patients receiving dantrolene have shown a 40 to 70% reduction in the skeletal muscle tension induced by direct electrical stimulation of the motor nerve with no alteration of…

Dantrium Intravenous

(Pharmaceutical)

DANTRIUM® INTRAVENOUS Procter & Gamble Pharmaceuticals Dantrolene Sodium Management of Malignant Hyperthermia Action And Clinical Pharmacology: Dantrolene is a muscle relaxant acting specifically on skeletal muscles. In isolated muscle preparations, dantrolene uncouples the excitation and contraction of skeletal muscles, probably by interfering with the release of calcium from the sarcoplasmic reticulum. In the anesthetic induced malignant hyperthermia syndrome, evidence points to a predisposing intrinsic abnormality of muscle tissue. In affected…

Dalacin T Topical Solution (Clindamycin Phosphate)

(Pharmaceutical)

DALACIN® T TOPICAL SOLUTION Pharmacia & Upjohn Clindamycin Phosphate Antibiotic Action And Clinical Pharmacology: Clindamycin phosphate is inactive in vitro but in vivo hydrolysis converts this compound to the antibacterially active clindamycin. Clindamycin has been shown to have in vitro activity against isolates of P. acnes which may account for its usefulness in acne. Clindamycin activity has been demonstrated in serum, urine and in comedonal extracts from acne patients. The…

Duvoid (Bethanechol Chloride)

(Pharmaceutical)

DUVOID® Roberts Bethanechol Chloride Parasympathomimetic Agent Action And Clinical Pharmacology: Bethanechol acts principally by producing the effects of stimulation of the parasympathetic nervous system. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores rhythmic peristalsis. Stimulation of the parasympathetic nervous system releases acetylcholine at the nerve endings….

Dyrenium (Triamterene)

(Pharmaceutical)

DYRENIUM® SmithKline Beecham Triamterene Diuretic Action And Clinical Pharmacology: Triamterene exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen ions. This natriuretic activity is limited by the amount of sodium reaching its site of action. Although triamterene blocks the increase in this exchange, which is stimulated by mineralocorticoids (chiefly aldosterone), its action takes place through a direct effect…

Duragesic (Fentanyl)

(Pharmaceutical)

DURAGESIC® Janssen-Ortho Fentanyl Opioid Analgesic Action And Clinical Pharmacology: Fentanyl is an opioid analgesic which interacts predominantly with the opioid receptor. Fentanyl produces analgesia, sedation, respiratory depression, constipation, and physical dependence but appears to have less emetic activity than other opioid analgesics. Fentanyl may produce muscle rigidity, miosis, cough reflex suppression, alterations in mood, bradycardia and broncho-constriction. Analgesic blood levels of fentanyl may cause nausea and vomiting directly by stimulating…

Janssen-Ortho (Lithium Carbonate)

(Pharmaceutical)

DURALITH® Janssen-Ortho Lithium Carbonate Antimanic Agent Action And Clinical Pharmacology: Although lithium is useful for its antimanic effect and in preventing relapses in patients with a clearcut diagnosis of bipolar affective disorder, it has very little, if any, direct effect on moods, normal or abnormal. Lithium alters sodium transport in nerve and muscle cells, effects a shift toward intraneuronal metabolism of catecholamines and has an inhibitory action on the intracellular…

Duricef (Cefadroxil)

(Pharmaceutical)

DURICEF™ Bristol Cefadroxil Antibiotic Action And Clinical Pharmacology: Cefadroxil is a cephalosporin with bactericidal activity. In vitro studies have shown that the antibacterial activity of the cephalosporins results from their ability to inhibit mucopeptide synthesis in the bacterial cell wall. Pharmacokinetics: Cefadroxil is well absorbed following oral administration with 93% of a 500 mg dose being recovered unchanged in the urine after 24 hours. Absorption of cefadroxil from the gastrointestinal…

Dulcolax (Bisacodyl Tablets)

(Pharmaceutical)

DULCOLAX® Boehringer Ingelheim Self Medication Division Bisacodyl Laxative Indications And Clinical Uses: For the treatment of occasional constipation. In the preparation for diagnostic procedures, in pre- and postoperative treatment, and in conditions which require defecation to be facilitated, the use of bisacodyl must be under medical supervision. Contra-Indications: In patients with ileus, intestinal obstruction, acute surgical abdominal conditions like acute appendicitis, acute inflammatory bowel diseases, and in severe dehydration. Bisacodyl…

Duoforte (Salicylic Acid)

(Pharmaceutical)

DUOFORTE® 27 Stiefel Salicylic Acid Verrucae Therapy Indications And Clinical Uses: For common, plantar and mosaic warts. Contra-Indications: Diabetics or patients with impaired blood circulation should not use this product without the advice of a health professional. Do not use on moles, birthmarks or unusual warts with hair growing from them. Do not use near eyes or mucous membranes. Manufacturers’ Warnings In Clinical States: Do not use on inflamed and/or…