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DESQUAM-X® Preparations Westwood-Squibb Benzoyl Peroxide Acne Therapy Indications And Clinical Uses: A topical aid for the treatment of acne vulgaris. Contra-Indications: Known sensitivity to any of the components. Precautions: Avoid contact with eyes and mucous membranes. Observe patients carefully for possible local irritation or sensitivity during long-term topical therapy. Apply with caution on neck, circumoral and/or other sensitive areas. If excessive dryness or irritation occurs, discontinue use. May bleach colored…

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

DEPROIC® Technilab Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Valproic acid exhibits anticonvulsant properties. While the exact mechanism of action is unknown, several investigators have proposed that the anticonvulsive effect of valproic acid can be related to increased gamma-amino-butyric acid (GABA) levels in the brain. The effect on the neuronal membrane is unknown. After oral administration, valproic acid is rapidly absorbed, reaching peak serum levels within 1 to 4 hours….

DEQUADIN® Preparations Roberts Dequalinium Chloride Antibacterial – Antifungal Indications And Clinical Uses: For the treatment of mouth and throat infections. Contra-Indications: Dequalinium chloride sensitivity. Precautions: If irritation persists or sensitization occurs, discontinue use and consult a physician. Adverse Reactions: Allergic reactions have been reported rarely. Dosage And Administration: Lozenges: 1 lozenge sucked slowly every 2 or 3 hours. In severe infections, increase frequency of administration. Oral Paint: Apply freely to…

DESENEX® Novartis Consumer Health Undecylenic Acid – Zinc Undecylenate Antifungal Action And Clinical Pharmacology: Undecylenic acid is an antifungal agent, effective in the treatment of superficial fungal infections of the skin, such as tinea pedis (athlete’s foot), tinea cruris (jock itch) and tina corporis due to T. rubrum, T. mentagrophytes and E. flocossum, exclusive of nails and hair area. tag_IndicationsIndications Indications And Clinical Uses: For the treatment and prevention of…

DEMULEN® 30 DEMULEN® 50 Searle Ethynodiol Diacetate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Demulen 30: Prevention of pregnancy. Demulen 50:…

DECA-DURABOLIN® Organon Nandrolone Decanoate Androgenic – Anabolic Steroid Indications And Clinical Uses: As adjunctive therapy in senile and postmenopausal osteoporosis. Anabolic steroids are without value as primary therapy but may be of value in adjunctive therapy. Equal or greater consideration should be given to diet, calcium balance, physiotherapy and good general health promoting measures, in pituitary dwarfism anabolic agents may be used with care until growth hormone is more available….

DDAVP® Tablets Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Although the bioavailability of orally ingested desmopressin…

DAUNOXOME® NeXstar Liposomal Daunorubicin Antineoplastic Action And Clinical Pharmacology: DaunoXome is a liposomal preparation of daunorubicin formulated to selectively target daunorubicin to solid tumors in situ. While in the circulation, this formulation protects the entrapped daunorubicin from chemical and enzymatic degradation, minimizes protein binding, and generally decreases uptake by normal tissues, as well as by the non-reticuloendothelial system. The specific mechanism by which DaunoXome is able to deliver daunorubicin to…

DALMANE® Roche Flurazepam HCl Hypnotic Action And Clinical Pharmacology: Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Flurazepam decreases sleep latency and number of awakenings for a consequent increase in total sleep time. The duration of hypnotic effect and the profile of unwanted effects may be influenced by the alpha (distribution) and beta (elimination) half-lives…