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HUMULIN® Lilly Insulin, Human Biosynthetic Antidiabetic Agent Action And Clinical Pharmacology: Humulin is a polypeptide hormone consisting of a 21 amino acid A-chain and a 30 amino acid B-chain linked by two disulfide bonds. Humulin is found to be chemically, physically, biologically and immunologically equivalent to pancreatic human insulin which differs slightly from porcine or bovine insulin in amino acid composition. Studies indicate immunogenicity problems with biosynthetic human insulin (BHI)…

HUMALOG™ Lilly Insulin Lispro Antidiabetic Agent Action And Clinical Pharmacology: Insulin lispro is a rapid-acting analogue of human insulin. Due to its quick onset of action, insulin lispro should be given within 15 minutes of a meal. Insulin lispro is created by inverting the natural Pro-Lys sequence in human insulin at positions 28 and 29 in the C terminal portion of the B-chain. This change in amino acid sequence slightly…

HUMATROPE® Lilly Somatropin Growth Stimulant Action And Clinical Pharmacology: Somatropin is a polypeptide hormone of recombinant DNA origin. The amino acid sequence is identical to that of human growth hormone of pituitary origin. Somatropin is synthesized in a strain of E. coli which has been modified by the addition of the gene for human growth hormone. Somatropin stimulates linear growth in pediatric patients lacking adequate normal endogenous growth hormone. Treatment…

HUMATIN™ Parke-Davis Paromomycin Sulfate Antibiotic Action And Clinical Pharmacology: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by S. rimosus var. paromomycinus. The drug is structurally related to neomycin, streptomycin and kanamycin. It is poorly absorbed after oral administration with almost 100% of the drug recoverable in the stool. Paromomycin is considered a luminal or contact amebicide since it acts principally in the intestinal lumen. Unlike tetracyclines, paromomycin is a…

HIBIDIL® 1:2000 Zeneca Chlorhexidine Gluconate Antiseptic Action And Clinical Pharmacology: Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have been found in man following oral…

Brand Names: HIBITANE® Skin Cleanser Manufacturer: Zeneca Generic Name: Chlorhexidine Gluconate Use: Antibacterial Skin Cleanser Action And Clinical Pharmacology Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have…

HEPARINS: LOW MOLECULAR WEIGHT General Monograph, Dalteparin Enoxaparin Nadroparin Tinzaparin Anticoagulant Action And Clinical Pharmacology: Low molecular weight heparins (LMWHs) are fragments of heparin produced by enzymatic or chemical depolymerization. They have an average molecular weight of 4 000 to 5 000 daltons (range 1 000 to 10 000 daltons) which is approximately one-third that of standard heparin. Most heparin molecules with molecular weights smaller than 5 400 daltons are…

HEXADROL® PHOSPHATE INJECTION Organon Teknika Dexamethasone Sodium Phosphate Corticosteroid Action And Clinical Pharmacology: After administration of the injection, dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a synthetic glucocorticoid which has 7 times the anti-inflammatory potency of prednisolone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties and is, therefore, particularly suitable for use in patients…

HEALON® HEALON® GV Pharmacia & Upjohn Sodium Hyaluronate Ophthalmosurgical Aid Description: Sodium hyaluronate is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Healon contains 10 mg/mL of sodium hyaluronate 5 000 and Healon GV contains 14 mg/mL of sodium hyaluronate 7 000 dissolved in physiological sodium chloride-phosphate buffer (pH 7.0 to 7.5). This high molecular weight polymer is made up of…

HALOTESTIN® Pharmacia & Upjohn Fluoxymesterone Androgenic – Anabolic Steroid Action And Clinical Pharmacology: Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body…