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MYCIGUENT® Pharmacia & Upjohn Neomycin Sulfate Topical Antibiotic Indications And Clinical Uses: The prevention and treatment of infection in minor skin breaks caused by cuts, scratches, burns and other injuries. Contra-Indications: Neomycin sensitivity. Precautions: Articles in current medical literature indicate an increase in the incidence of patients sensitive to neomycin. The possibility of such a reaction should be borne in mind. Discontinue use if sensitization occurs. As with any antibiotic…

MYLANTA™ Preparations Warner-Lambert Consumer Healthcare Aluminum Hydroxide – Magnesium Hydroxide Compound Antacid – Antiflatulent Indications And Clinical Uses: The treatment and relief of symptoms of peptic ulcer, gastritis, hiatus hernia, hyperacidity, and the management of gastrointestinal disorders accompanied by excessive gas or flatus. Contra-Indications: Alkalosis, hypermagnesemia, where distention may be due to partial or complete intestinal obstruction. Not recommended for severely debilitated patients or those with impaired renal function. Precautions:…

MYOCHRYSINE® Rh´ne-Poulenc Rorer Sodium Aurothiomalate Antirheumatic Agent Action And Clinical Pharmacology: Sodium aurothiomalate exhibits anti-inflammatory, antiarthritic and immunomodulating effects. The predominant clinical effect of sodium aurothiomalate appears to be suppression of the synovitis in the active stage of the rheumatoid disease. The precise mechanism of action is unknown but it has been suggested that the drug may act by inhibiting cell-mediated and humoral immune mechanisms. Additional modes of action include…

MYLERAN® Glaxo Wellcome Busulfan Antileukemic Action And Clinical Pharmacology: Busulfan is a bifunctional alkylating agent. Binding to DNA is believed to play a role in its mode of action, and di-guanyl derivatives have been isolated, but interstrand crosslinking has not been conclusively demonstrated. The basis for the uniquely selective effect of busulfan on granulocytopoiesis is not fully understood. Pharmacokinetics: Early pharmacokinetic studies were carried out with radioactively labelled busulfan. More…

LUTREPULSE™ Ferring Gonadorelin Acetate Ovulatory Agent Action And Clinical Pharmacology: Gonadorelin is a synthetic decapeptide that has the same amino acid sequence as endogenous gonadotropin-releasing hormone (GnRH) synthesized in the human hypothalamus and in various neurons terminating in the hypothalamus. Its pharmacological and toxicological profile is therefore identical to that of endogenous GnRH. Under physiologic conditions, GnRH is released by the hypothalamus in a pulsatile fashion. The primary effect of…

LUVOX® Solvay Pharma Fluvoxamine Maleate Antidepressant – Antiobsessional Agent Action And Clinical Pharmacology: The antidepressant and antiobsessional actions of fluvoxamine are believed to be related to its selective inhibition of presynaptic serotonin re-uptake in brain neurones. There is minimum interference with noradrenergic processes, and, in common with several other specific inhibitors of serotonin uptake, fluvoxamine has very little in vitro affinity for a1, a2, b1, dopamine2, histamine1, serotonin1, serotonin2 or…

LUDIOMIL® Novartis Pharmaceuticals Maprotiline HCl Antidepressant Action And Clinical Pharmacology: Maprotiline has been shown to exhibit an antidepressant action. Maprotiline strongly inhibits the uptake of norepinephrine in the brain and peripheral tissues, but has a notable lack of serotonergic uptake inhibition. It has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline has a strong antihistaminic activity and a weaker anticholinergic activity. Maprotiline also exerts a sedative effect on the…

LUPRON DEPOT® 3.75 mg/7.5 mg Abbott/TAP Pharmaceuticals Leuprolide Acetate Leuprolide Acetate for Depot Suspension Gonadotropin-releasing Hormone Analog for Management of Central Precocious Puberty in Children Action And Clinical Pharmacology: Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LHRH). The analog possesses greater potency than the natural hormone. When administered as indicated, leuprolide acts as a potent inhibitor of gonadotropin production. It is chemically unrelated…

LUPRON® DEPOT® 3.75 mg Abbott Leuprolide Acetate for Depot Suspension Gonadotropin-releasing Hormone Analog Action And Clinical Pharmacology: Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH or LHRH). The analog possesses greater potency than the natural hormone. When administered as indicated, leuprolide acts as a potent inhibitor of gonadotropin production. It is chemically unrelated to steroids. Unlike steroid hormones, leuprolide exerts specific action on the pituitary gonadotrophs…

LOVENOX® Rhône-Poulenc Rorer Enoxaparin Sodium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Enoxaparin is a low molecular weight heparin fragment, which is obtained by controlled depolymerization of natural heparin from porcine intestinal mucosa. It possesses antithrombotic action. Enoxaparin is composed of molecules with and without a specially characterized pentasaccharide, the antithrombin binding site, that is essential for high affinity binding to the plasma protein antithrombin (formerly referred to as antithrombin…