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LOSEC® Astra Omeprazole Magnesium H KATPase Inhibitor Note: When used in combination with amoxicillin, clarithromycin or metronidazole, the product monographs for those agents must be consulted and followed. Action And Clinical Pharmacology: Omeprazole inhibits the gastric enzyme H KATPase (the proton pump) which catalyzes the exchange of Hand K It is effective in the inhibition of both basal acid secretion and stimulated acid secretion. The inhibition is dose dependent. Daily…

LOCACORTEN® VIOFORM® Novartis Pharmaceuticals Flumethasone Pivalate – Clioquinol Topical Corticosteroid – Antibacterial – Antifungal Action And Clinical Pharmacology: Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching. Clioquinol, the antimicrobial component of Locacorten…

LOCACORTEN® VIOFORM® Eardrops Novartis Flumethasone Pivalate – Clioquinol Topical Aural Corticosteroid – Antibacterial – Antifungal Action And Clinical Pharmacology: Flumethasone pivalate is a moderately potent difluorinated glucocorticoid with anti-inflammatory, antipruritic, and vasoconstrictive properties. As it is a pivalate, its action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching. Clioquinol, the antimicrobial component of Locacorten Vioform…

LOCASALEN® Novartis Flumethasone Pivalate – Salicylic Acid Topical Corticosteroid – Squamolytic Action And Clinical Pharmacology: Locasalen exhibits pronounced anti-inflammatory, anti-allergic antiproliferative and antipruritic effects. Flumethasone pivalate, a topical corticoid of proven efficacy, is in solution in the ointment base rather than as suspended microcrystals and attains a higher degree of penetration into the skin where it remains active in the epidermis for a long period of time. The salicylic acid…

LITHANE™ Pfizer Lithium Carbonate Antimanic Agent Action And Clinical Pharmacology: Although lithium is useful for its antimanic effect and in preventing relapses in patients with a clearcut diagnosis of bipolar affective disorder, it has very little, if any, direct effect on moods, normal or abnormal. Lithium alters sodium transport in nerve and muscle cells, effects a shift toward intraneuronal metabolism of catecholamines and has an inhibitory action on the intracellular…

LIPACTIN® Novartis Consumer Health Heparin Sodium – Zinc Sulfate Symptomatic Treatment of Herpes Simplex I Action And Clinical Pharmacology: Lipactin is composed of heparin and zinc for topical application. Topical application of heparin produces accumulation of the heparin molecules in the corium of the skin while insignificant amounts are absorbed through the skin. Oral administration of heparin is associated with negligible anticoagulant effect as heparin is immediately metabolized in the…

LIPITOR™ Parke-Davis Atorvastatin Calcium Lipid Metabolism Regulator Action And Clinical Pharmacology: Atorvastatin is a synthetic lipid-lowering agent. It is a selective, competitive inhibitor of 3-hydroxy- 3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing…

LIDOSPORIN® Cream LIDOSPORIN® Ear Drops Warner-Lambert Consumer Healthcare Polymyxin B Sulfate – Gramicidin – Lidocaine HCl Polymyxin B Sulfate – Lidocaine HCl Antibiotic – Anesthetic – Antipruritic Indications And Clinical Uses: Cream: Topical relief of pain and itching; also for the treatment and prevention of infections in minor cuts, wounds, and burns. Ear Drops: The prevention of exacerbations and treatment of infection due to susceptible organisms, relief of pain and…

LIDEMOL® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella) and untreated purulent bacterial infections. Hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: Pregnancy and Lactation: The…

LIDEX® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Contraindicated in individuals with a history of hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: Pregnancy and…