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PHARMORUBICIN® Pharmacia & Upjohn Epirubicin HCl Antineoplastic Action And Clinical Pharmacology: The mechanism of action of epirubicin, although not completely elucidated, is mainly related to its ability to bind to nucleic acids by intercalation of the planar anthracycline nucleus with the DNA double helix. Binding to cell membranes as well as to plasma proteins may also be involved. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding,…

PERI-COLACE® Roberts Docusate Sodium – Casanthranol Laxative – Stool Softener Indications And Clinical Uses: Occasional or temporary constipation. Contra-Indications: When symptoms of appendicitis or intestinal obstruction are present. Precautions: Do not use in presence of abdominal pain, nausea, fever or vomiting. Use with caution in lactating women as the compound may cause increased stooling in the infant. Frequent or prolonged use may result in dependence on laxatives. Do not administer…

PERIDEX® Zila Pharmaceuticals Chlorhexidine Gluconate Antigingivitis Action And Clinical Pharmacology: Chlorhexidine provides antimicrobial activity during oral rinsing which is maintained between rinsings. Microbiologic sampling of plaque has shown a general reduction of both aerobic and anaerobic bacterial counts ranging from 54 to 97% through 6 months’ clinical use. Rinsing with chlorhexidine inhibits the buildup and maturation of plaque by reducing certain microbes regarded as gingival pathogens, thereby reducing gingivitis. Chlorhexidine…

PENTOTHAL® Abbott Thiopental Sodium I.V. Anesthetic Indications And Clinical Uses: As the sole anesthetic agent for brief (15-minute) procedures; for induction of anesthesia prior to administration of other anesthetic agents; to supplement regional anesthesia; to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation; for the control of convulsive states during or following inhalation anesthesia, local anesthesia, or other causes; in neurosurgical patients with increased intracranial…

PedvaxHIB® MSD Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) Vaccine Action And Clinical Pharmacology: Disease Epidemiology: Prior to the introduction of Haemophilus b conjugate vaccines, H. influenzae type b (Haemophilus b) was the most frequent cause of bacterial meningitis and a leading cause of serious systemic bacterial disease in young children worldwide. Haemophilus b disease occurred primarily in children under 5 years of age in the United States prior to…

PEDIAPRED® Rh´ne-Poulenc Rorer Prednisolone Sodium Phosphate Glucocorticoid – Anti-inflammatory Action And Clinical Pharmacology: Prednisolone sodium phosphate is a synthetic adrenocortical steroid derivative with predominantly glucocorticoid properties possessing anti-inflammatory and immunosuppressive action. Prednisolone sodium phosphate belongs to the pharmacologic class of glucocorticoid/anti-inflammatory drugs which, following systemic absorption, diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes may enter the cell nucleus, bind to DNA and stimulate transcription of…

PEDIASURE™ Abbott Therapeutic Nutrient Description: PediaSure liquid nutrition for children is an isotonic enteral nutritional product designed to provide complete balanced nutrition for children 1 to 10 years of age. Fed either by tube or orally, PediaSure can be used as total enteral nutrition support or as a supplement. Indications And Clinical Uses: Enteral nutritional support by tube or by mouth for children 1 to 10 years of age. Support…

PAS SODIUM General Monograph, CPhA Aminosalicylate Sodium Antimycobacterial Pharmacology: Para-aminosalicylate sodium is the sodium salt of para-aminosalicylic acid (PAS). Note: Aminosalicylate sodium differs from 5-aminosalicylic acid (5-ASA), which is used for the treatment of inflammatory bowel disease. PAS sodium is a highly specific bacteriostatic agent active only against M. tuberculosis. PAS sodium competitively inhibits the formation of dihydrofolic acid from aminobenzoic acid, thus preventing bacterial synthesis of folic acid required…

PARNATE® SmithKline Beecham Tranylcypromine Sulfate Antidepressant Action And Clinical Pharmacology: Tranylcypromine is a nonhydrazine (MAO) inhibitor with a rapid onset of activity. It increases the concentration of epinephrine, norepinephrine and serotonin in storage sites in the nervous system. In theory, the increased concentration of monoamines in the brainstem is the basis for its antidepressant activity. Tranylcypromine differs from other MAO inhibitors in being a reversible inhibitor. When tranylcypromine is withdrawn,…

Brand Names: PALAFER® Manufacturer: SmithKline Beecham Generic Name: Ferrous Fumarate Use: Anemia Therapy Indications And Clinical Uses Increased iron requirements as in childhood, adolescence, and pregnancy; blood losses, overt or occult. Characterized microcytic hypochromic anemia; faulty iron absorption following gastrectomy; iron loss due to menstruation, sub-clinical iron deficiencies in adolescent girls due to precarious iron balance, and geriatrics. Contraindications Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of…