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SUPRES® Merck Frosst Methyldopa-Chlorothiazide Antihypertensive Action and Clinical Methyldopa: Methyldopa, an antihypertensive agent, is an aromatic-amino-acid decarboxylase inhibitor in animals and in man. Although the mechanism of action has yet to be conclusively demonstrated, the antihypertensive effect of methyldopa probably is due to its metabolism to alpha-methyl-norepinephrine, which then lowers arterial pressure by stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity. Methyldopa has been…

SULTRIN® Janssen-Ortho Triple Sulfa Vaginitis Therapy Indications And Clinical Uses: Postoperative vaginitis or cervicitis, nonspecific vaginitis, ulcerative vaginitis and related gynecological conditions. Contra-Indications: Sulfonamide sensitivity; kidney disease. Precautions: Although some absorption of sulfonamide may occur through the vaginal mucosa, systemic reactions attributable to this are infrequent, as are local sensitivity reactions such as increased discomfort or a burning sensation following the use of this product. However, as with all sulfonamides,…

SUPLASYN® Paladin Sodium Hyaluronate Synovial Fluid Replacement Action and Clinical Hyaluronic acid is a naturally occurring mucopolysaccharide present in the connective tissue of all animals. It is a biological polymer composed of repeating units of two sugars, D-glucuronic acid and N-acetylglycosamine, linked by glycosidic bonds. This configuration for hyaluronic acid is the same for all living species from bacteria to man. High concentrations are found in synovial fluid, the vitreous…

SUPRAX® Rhône-Poulenc Rorer Cefixime Antibiotic Action and Clinical Pharmacology: Cefixime exerts its bactericidal effect by attaching to penicillin-binding proteins and inhibiting peptidoglycan synthesis, thus causing damage to the bacterial cell wall.: Pharmacokinetics: Following oral dosing, cefixime attains peak serum levels in approximately 4 hours. The half-life is about 3 to 4 hours and is not dose dependent. Cefixime is excreted by renal and biliary mechanisms. About 50% of the absorbed dose is excreted…

SUPRANE® AstraZeneca Desflurane Inhalation Anesthetic Action and Clinical Pharmacology: Desflurane is a volatile inhalational anesthetic whose low solubility (blood/gas partition coefficient equals 0.42) permits rapid variation in anesthetic depth. If anesthesia is maintained with inflow rates of greater than 2 L/min, the alveolar concentration is usually within 10% of the inspired concentration. It is not necessary to deliver concentrations of desflurane far in excess of the desired end-tidal concentration (“overpressurization”…

SULCRATE® SUSPENSION PLUS Hoechst Marion Roussel Sucralfate Gastroduodenal Cytoprotective Agent Action and Clinical Pharmacology: Sucralfate exerts a generalized gastric cytoprotective effect by enhancing natural mucosal defense mechanisms. Studies conducted in animals and clinical trials in humans have demonstrated that sucralfate can protect the gastric mucosa against various irritants such as alcohol, ASA, hydrochloric acid, sodium hydroxide or sodium taurocholate. In addition, sucralfate has been demonstrated to have a greater affinity…

SULFACET-R® Dermik Sulfacetamide Sodium-Sulfur Acne Therapy Indications And Clinical Uses: Severe acne vulgaris, seborrheic dermatitis, bacterial folliculitis and related conditions. Contra-Indications: Hypersensitivity to the sulfonamides as indicated by a previous toxic reaction to them (e.g. agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice, or contact dermatitis). Precautions: Sulfur may cause reddening and scaling of the epidermis, but if undue skin irritation develops or increases, discontinue use and consult a…

SULFOXYL® Stiefel Sulfur-Benzoyl Peroxide Acne Vulgaris Therapy Availability And Storage: Each mL of lotion contains: sulfur 2% and benzoyl peroxide 5% in a vanishing lotion base. Nonmedicinal ingredients: glyceryl monostearate, imidurea, isopropyl palmitate, PEG 1000 monostearate, propylene glycol, purified water, stearic acid, xantham gum and zinc stearate. Plastic bottles of 60 mL. Protect from heat. SULFOXYL® Stiefel Sulfur–Benzoyl Peroxide Acne Vulgaris Therapy

SULFUR SOAP Stiefel Acne Therapy Availability And Storage: Each g of neutral soap contains: precipitated sulfur USP 10%. Nonmedicinal ingredients: butylated hydroxytoluene, fragrance, purified water, soap chips and trisodium HEDTA. Bars of 75 g. SULFUR SOAP Stiefel Acne Therapy

SUCCINYLCHOLINE CHLORIDE INJECTION USP Bioniche Neuromuscular Blocking Agent Availability And Storage: Each mL of sterile solution contains: succinylcholine chloride (anhydrous base) 20 mg equivalent to dihydrate 22 mg. Nonmedicinal ingredients: hydrochloric acid (to adjust pH) and sodium chloride (for isotonicity). Ampuls of 5 mL, boxes of 10. Multiple dose vials of 10 and 20 mL (also contains methylparaben and propylparaben), trays of 10. Refrigerate (2 to 8°C) to prevent a…