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PANCREASE® PANCREASE® MT Janssen-Ortho Pancrelipase Digestant Action And Clinical Pharmacology: The enteric-coated microtablets resist gastric inactivation and deliver predictable, high levels of biologically active pancreatic enzymes (lipase, amylase, and protease) into the duodenum. The enzymes catalyze the hydrolysis of fats into glycerol and fatty acids, proteins into proteoses and derived substances, and starch into dextrins and sugars. Pharmacokinetics: Absorption: The intestinal bioavailability of Pancrease MT 16 capsules was determined, in…

PANOCAINE® Hoechst Marion Roussel Benzocaine – Tetracaine HCl Oral Topical Anesthetic Action And Clinical Pharmacology: Panocaine is a local anesthetic of the ester type which rapidly produces surface anesthesia following application to the mucosa of the oral cavity in clinical dentistry. Panocaine has a short duration of action and is ineffective when applied to intact skin. Indications And Clinical Uses: For use in the oral cavity for minimizing the pain…

PANECTYL® Rhône-Poulenc Rorer Trimeprazine Tartrate Antipruritic – Antihistamine Action And Clinical Pharmacology: Trimeprazine is a propylamino phenothiazine derivative with reduced central activity and enhanced antihistaminic and antipruritic effects. It is a potent histamine antagonist. Trimeprazine possesses sedative properties, and is active in suppressing apomorphine induced vomiting in the dog. No evidence of teratogenic effect has been demonstrated in animal studies. Indications And Clinical Uses: Pruritus regardless of site or etiology….

PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PYRIBENZAMINE® Novartis Consumer Health Tripelennamine HCl Antihistamine Indications And Clinical Uses: Seasonal or nonseasonal allergic reactions. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or…

PROTROPIN® Roche Somatrem Growth Hormone Action And Clinical Pharmacology: Somatrem is a polypeptide (methionyl human growth hormone) produced by recombinant DNA technology using the gene for human growth hormone. Somatrem has the same amino acid sequence as pituitary-derived human growth hormone plus an additional amino acid, methionine, on the N-terminus of the molecule. The two molecules also have the same disulfide bond arrangement and the same secondary and tertiary structure….

PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestin Action And Clinical Pharmacology: Medroxyprogesterone, an orally active progestational steroid (progestin) derived from a natural source (soy beans), when administered to women with adequate levels of estrogen (endogenous or exogenous), transforms a proliferative endometrium into a secretory endometrium. Furthermore, the anticancer activity of medroxyprogesterone at pharmacologic doses, may be dependent on its effect on the hypothalamic/pituitary/gonadal axis, estrogen receptors and metabolism of steroids…

PROVIODINE® Rougier Povidone-Iodine Antiseptic Action And Clinical Pharmacology: Proviodine is iodine complexed with povidone (polyvinyl-pyrrolidone). The compound is soluble in water forming a golden brown solution. Like iodine, the solution of the iodine complex is bactericidal and fungicidal. However, unlike solutions of iodine, it is non-staining. The antiseptic action of povidone-iodine solutions is due to the available iodine present in the complex. Indications And Clinical Uses: Derma: Useful as a…

PROSTIN® E2 Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Orally administered dinoprostone stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions observed in the term uterus during spontaneous labor. Whether or not this action results from a direct or indirect effect of dinoprostone on the myometrium has not been determined with certainty. Dinoprostone’s ability to stimulate gastrointestinal tract smooth…

PROSTIN® VR Pharmacia & Upjohn Alprostadil Prostaglandin Action And Clinical Pharmacology: Alprostadil (also known as prostaglandin E1) relaxes the ductus arteriosus in early postnatal life and supports its patency when continuously infused i.v. or intra-arterially in neonates with congenital heart defects who depend on a patent ductus for survival. The desired pharmacological effects are obtained with an initial dosage of 0.1 µg/kg/minute. Higher doses do not offer added benefit. Postnatally…