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ISORDIL® Wyeth-Ayerst Isosorbide Dinitrate Coronary Vasodilator Action And Clinical Pharmacology: The basic action of isosorbide dinitrate is the relaxation of smooth muscle. Relaxation of peripheral vascular smooth muscle and pooling results in the reduction of preload and afterload on the left ventricle. The effect of the long acting nitrate appears to be mainly peripheral. Although isosorbide dinitrate dilates the coronary arteries there is no incontrovertible evidence that it relieves ischemic…

ISOSOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete liquid tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function, when low-residue feeding is required. Because it is slightly flavored, Isosource HN may be appropriate for oral administration in patients experiencing altered or heightened taste perceptions (e.g., individuals undergoing radiation and chemotherapy treatment). Precautions: Not for parenteral administration. Dosage And Administration: 1 500…

ISOSOURCE® VHN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, fibre containing, complete liquid tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 1 250 mL or 5 220 kJ (5 cans or 1 250 kcal) provides at least…

ISONIAZID General Monograph, INH Isonicotinic Acid Hydrazide Isonicotinylhydrazide Antimycobacterial Pharmacology: Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. The mode of action is unknown but the drug is firmly bound to actively growing, sensitive, tubercle bacilli and does not affect these organisms when they are in the metabolic…

ISOPRINOSINE® Rivex Pharma Inosiplex Subacute Sclerosing Panencephalitis Therapy Action And Clinical Pharmacology: Mechanism(s) that might explain the results of the clinical studies employing inosiplex have not been completely elucidated. However, possible antiviral and immunomodulating properties of this drug may be involved. Serum uric acid concentration rose with increasing inosiplex doses. Hyperuricemic levels (greater than 7.5 mg%) were seen at doses equal to or exceeding 3 g/day. At doses of 4…

ISOPTIN® I.V. Knoll Verapamil HCl Antiarrhythmic Action And Clinical Pharmacology: Mode of Action: The mechanism of action of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium ion through the slow channel (calcium ion antagonism) without affecting to any…

ISOPTIN® SR Knoll Verapamil HCl Antihypertensive Agent Action And Clinical Pharmacology: Verapamil is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist) that exerts its pharmacological effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conducting and contractile myocardial cells. Verapamil exerts antihypertensive effects by inducing vasodilation and reducing peripheral vascular resistance usually without reflex…

ISOCAL® Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: Nutritionally complete and well-balanced to provide the total dietary needs of most tube-fed patients. Precautions: Give additional water as needed to meet the patient’s requirements. Particular attention should be given to water supply for comatose and unconscious patients and others who cannot express the usual sensations of thirst. Additional water is important also when renal concentrating ability is impaired, when there…

ISOCAL® with Fibre Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A complete liquid diet formulated to provide the nutrient density of Isocal with the associated advantages of fibre. Precautions: Give additional water as needed to meet the patient’s requirements. Particular attention should be given to water supply for comatose and unconscious patients and others who cannot express the usual sensations of thirst. Additional water is important also when renal…

ISOCAL® HN Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A complete liquid diet formulated to provide well balanced nutrition when used as the sole source of nourishment, particularly in tube fed patients who have normal digestive function. The non-protein-calorie-to-nitrogen ratio of Isocal HN is indicated for patients with burns, sepsis, major injury and surgery. When protein needs are increased with increasing levels of stress; e.g., protein requirement for basic…