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ISOMIL® Preparations Abbott Milk-Free Formula Nutritional Formula Indications And Clinical Uses: For infants and children with an allergy or sensitivity to cow’s milk. A feeding following diarrhea. A feeding for patients with disorders for which lactose should be avoided: lactase deficiency, lactose intolerance and galactosemia. Precautions: Shake can well before opening. Shake bottle well before feeding. Dosage: The number of mL to be offered to the baby in 24 hours…

IONAMIN® Rhône-Poulenc Rorer Phentermine (Resin Complex) Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drug of this class used in obesity, amphetamine (d- and dl-amphetamine). Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity…

IOPIDINE® 1% IOPIDINE® 0.5% Alcon Apraclonidine HCl Controls Postsurgical Intraocular Pressure Glaucoma Therapy Action And Clinical Pharmacology: Apraclonidine is a relatively selective alpha adrenergic agonist and does not have significant membrane stabilizing (local anesthetic) activity. When instilled into the eye, apraclonidine has the action of reducing intraocular pressure. The precise mechanism of the ocular hypotensive action of apraclonidine is not completely established at this time. Aqueous fluorophotometry studies in man…

IPECAC SYRUP General Monograph, Emetic Pharmacology: Ipecac induces vomiting by both gastric irritation and central stimulation of the chemoreceptor trigger zone. Approximately 95% of patients vomit within 15 to 30 minutes of administration of a therapeutic dose and vomiting usually persists for 30 minutes to 2 hours. Approximately 28 to 60% of an ingested toxin will be removed by emesis if ipecac is given within 5 minutes following ingestion of…

IRON SALTS General Monograph Anemia Therapy Pharmacology: Iron is an important component of a number of enzymes necessary for energy transfer. It is also present in hemoglobin and myoglobin and is important in the metabolism of catecholamines and the functioning of neutrophils. Administration of iron preparations corrects erythropoietic abnormalities which are due to deficiency of iron. Iron does not stimulate erythropoiesis nor does it correct hemoglobin disturbances not caused by…

ISMO® Wyeth-Ayerst Isosorbide-5-Mononitrate Antianginal Action And Clinical Pharmacology: As with other organic nitrates, the principal pharmacological action of isosorbide-5-mononitrate, the major active metabolite of isosorbide dinitrate, is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure…

INTROPIN® DuPont Pharma Dopamine HCl Sympathomimetic Action And Clinical Pharmacology: Dopamine exerts an inotropic effect on the myocardium resulting in an increased cardiac output. Dopamine produces less increase in myocardial oxygen consumption than isoproterenol and its use is usually not associated with a tachyarrhythmia. Clinical studies indicate that dopamine at low and intermediate therapeutic doses usually increases systolic and pulse pressure with either no effect or a slight increase in…

INOCOR® Sanofi Amrinone Lactate Inotrope – Vasodilator Action And Clinical Pharmacology: Amrinone is a positive inotropic agent with vasodilatory activity, different in structure and mode of action from either digitalis glycosides or catecholamines. Its mechanism of action has not been fully elucidated. Experimental evidence indicates that it is not a beta-adrenergic agonist. It inhibits myocardial cyclic adenosine monophosphate phosphodiesterase (c-AMPase) activity and increases cellular levels of c-AMP. Unlike digoxin, it…

INTAL® SPINCAPS® INTAL® NEBULIZER SOLUTION Rh´ne-Poulenc Rorer Sodium Cromoglycate Bronchial Asthma Prophylaxis Action And Clinical Pharmacology: In vitro and in vivo animal studies have shown that sodium cromoglycate inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. Sodium cromoglycate acts by inhibiting the release of mediators from mast cells. Studies show that sodium cromoglycate indirectly blocks calcium ions from entering the mast cell, thereby preventing mediator release….

INTAL® INHALER INTAL® SYNCRONER® Rh´ne-Poulenc Rorer Sodium Cromoglycate Asthma Prophylaxis Action And Clinical Pharmacology: In vitro and in vivo animal studies have shown that sodium cromoglycate inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. Sodium cromoglycate acts by inhibiting the release of mediators from mast cells. Studies show that sodium cromoglycate indirectly blocks calcium ions from entering the mast cell, thereby preventing mediator release. Sodium cromoglycate…