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MESTINON® MESTINON®-SR ICN Pyridostigmine Bromide Antimyasthenic – Cholinergic Action And Clinical Pharmacology: Pyridostigmine is a cholinergic agent which acts primarily by the inhibition of cholinesterase. It enhances cholinergic action by facilitating the transmission of impulses across neuromuscular junctions. It also has a direct cholinomimetic effect on skeletal muscle and possibly on autonomic ganglion cells and neurons of the CNS. Because of its quaternary ammonium structure, moderate doses of pyridostigmine do…

METANDREN® Novartis Methyltestosterone Oral Androgen Indications And Clinical Uses: In the male: replacement therapy in hypogonadism, eunuchoidism, the climacteric, and other conditions due to loss, atrophy or hypofunction of the testes. In the female: palliation of androgen-responsive, advancing, inoperable breast cancer in women who are more than 1 year, but less than 5 years, postmenopausal or who have been proven to have a hormone dependent tumor, as shown by previous…

METHOTREXATE SODIUM INJECTION USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which…

MERSYNDOL® with CODEINE Hoechst Marion Roussel Acetaminophen – Codeine Phosphate – Doxylamine Succinate Analgesic Action And Clinical Pharmacology: Acetaminophen is the major metabolite of phenacetin and acetanilid. Acetaminophen is an effective and fast-acting analgesic which acts centrally to relieve mild to moderate pain. Animal and clinical studies have shown acetaminophen to have antipyretic and analgesic activity equal to that of ASA. Unlike the salicylates, acetaminophen does not interfere with tubular…

METAMUCIL® Preparations Procter & Gamble Psyllium Hydrophilic Mucilloid Laxative – Fibre Supplement Indications And Clinical Uses: The relief of chronic, atonic, spastic and rectal constipation and for the constipation accompanying pregnancy, convalescence and advanced age. As adjunctive therapy in the constipation of mucous and ulcerative colitis and diverticulitis. To provide supplementary dietary fibre in special dietary programs. Also useful in the management of hemorrhoids and following anorectal surgery. Contra-Indications: Presence…

MERREM® Zeneca Meropenem Antibiotic Action And Clinical Pharmacology: Meropenem is a broad spectrum, b-lactamase-resistant, carbapenem antibiotic for parenteral administration. The bactericidal activity of meropenem results from the inhibition of bacterial cell wall synthesis. Meropenem readily penetrates through the cell wall of most gram-positive and gram-negative bacteria to reach penicillin binding protein (PBP) targets. Its greatest affinity is for PBP 2 of E. coli, PBP 2 and 3 of P. aeruginosa…

MERITENE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: As a supplement or as a tube feeding, recommended whenever protein needs are increased and energy requirements are moderate. Meritene Powder provides 18 g protein and 275 kcal (1 150 kJ)/serving. Precautions: Not for parenteral use. Dosage And Administration: Oral: As a supplement with or between meals: 1 to 3 servings daily, 1 150 to 3 450 kJ (275 to 825…

MELLARIL® Novartis Pharmaceuticals Thioridazine HCl Tranquilizer – Antipsychotic Action And Clinical Pharmacology: The basic pharmacological profile of thioridazine is similar to that of other phenothiazines, but there are significant differences in the clinical spectrum when compared with other agents of this class. The distinctive features of thioridazine are its low propensity to cause extrapyramidal side effects and its low antiemetic activity. Thioridazine has a wide therapeutic margin. At low and…

MENINGOCOCCAL POLYSACCHARIDE VACCINE, GROUPS A, C, Y AND W-135 COMBINED, MENOMUNE® Connaught Vaccine Action And Clinical Pharmacology: Meningitis can be caused by a variety of microorganisms including several sero-groups of meningococci. This vaccine will not stimulate protection against infections caused by organisms other than Groups A, C, Y and W-135 meningococci. It has been demonstrated that the presence of human serum bactericidal antibodies to meningococcal antigens is strongly correlated with…

MEDROL® VERIDERM® Cream Pharmacia & Upjohn Methylprednisolone Topical Glucocorticoid Indications And Clinical Uses: Noninfected dermatoses, including allergic dermatoses, pruritus ani and vulvae, atopic and seborrheic dermatitis and contact dermatitis, induced by poison ivy, cosmetics, chemicals or drugs. Contra-Indications: Tuberculosis of the skin, herpes simplex, vaccinia, varicella and other cutaneous infections for which an effective agent is not available for simultaneous application. Do not use in the eye or in patients…