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MEFOXIN® MSD Cefoxitin Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies demonstrate that the bactericidal action of cefoxitin, a cephamycin derived from cephamycin C, results from the inhibition of bacterial cell wall synthesis. Evidence suggests that the methoxy group in the 7a position is responsible for the resistance of cefoxitin to degradation by bacterial beta-lactamases. Cefoxitin is poorly absorbed orally in humans. Cefoxitin, administered parenterally, produces high serum and…

MEGRAL® Glaxo Wellcome Ergotamine Tartrate – Cyclizine HCl – Caffeine Hydrate Migraine Therapy Indications And Clinical Uses: The treatment of vascular headache, migraine and related conditions where distention of cranial vessels appears to be the cause. Contra-Indications: Sepsis, occlusive vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, coronary artery disease, thrombophlebitis, Raynaud’s disease), thyrotoxicosis, anemia, renal or hepatic disease, hypertension, angina pectoris, peptic ulcer, infectious states, malnutrition, severe pruritus, pregnancy,…

MEGACE® MEGACE® OS Bristol Megestrol Acetate Antineoplastic – Progestogen – Antianorexic – Anticachectic Antianorexic – Anticachectic Action And Clinical Pharmacology: The precise mechanism of action by which megestrol produces its antineoplastic effects is unknown at present. Pharmacologic doses of megestrol exerted a direct cytotoxic effect on human breast cancer cells in vitro and proved capable of modifying and abolishing the stimulatory effects of estrogen on breast cancer cell lines. Megestrol…

MD-76® Mallinckrodt Diatrizoate Meglumine – Diatrizoate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, MD-76 is rapidly transported through the bloodstream to the kidneys and is excreted unchanged in the urine by glomerular filtration. When urinary tract obstruction is severe enough to block glomerular filtration, the agent appears to be excreted by the tubular epithelium. Renal accumulation is sufficiently rapid that the period of maximal opacification of the…

Measles Virus Vaccine, Live Attenuated (Dried) Connaught Vaccine Action And Clinical Pharmacology: Measles Virus Vaccine, Live, Attenuated (Dried) is prepared in avian leucosis-free chick embryo fibroblast cultures from the Edmondston Strain of attenuated measles virus, obtained from Dr. J.F. Enders and given an additional 69 passages in chick embryo cell cultures. The diluent for reconstitution for the 1 dose vial is Water for Injection (WFI). The diluent for reconstitution for…

MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Aluminum Chlorhydroxide – Sulfur Acne Therapy Action And Clinical Pharmacology: Medrol Acne Lotion has an anti-inflammatory action by virtue of its content of methylprednisolone, as astringent and antiperspirant action by virtue of its content of aluminum chlorhydroxide and a keratolytic effect by virtue of its sulfur content. Sulfur has also demonstrated some antibacterial activity at the concentration used. Indications And Clinical Uses:…

MEDROL® Pharmacia & Upjohn Methylprednisolone Glucocorticoid Indications And Clinical Uses: Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia. Nonsuppurative thyroiditis. Hypercalcemia associated with cancer. Nonendocrine Disorders: Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode…

MAVIK™ Knoll Trandolapril Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Trandolapril is a nonsulfydryl angiotensin converting enzyme (ACE) inhibitor, which is used in the treatment of mild to moderate essential hypertension and following acute myocardial infarction in stabilized patients with left ventricular dysfunction. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the pharmacologically active substance, angiotensin II, which is a vasopressor…

MAXERAN® Hoechst Marion Roussel Metoclopramide HCl Modifier of Upper Gastrointestinal Tract Motility – Antiemetic Action And Clinical Pharmacology: Metoclopramide is a benzamide derivative, structurally related to procainamide and sulpiride. As with sulpiride, it has dopamine-antagonist activity with selective affinity for D-2 (non-adenylate cyclase-linked) receptors. The behavioral, motor, and neuroendocrine effects of metoclopramide have been linked to its antidopaminergic activity. Metoclopramide has antiemetic properties, which are believed to result from its…

MAXIPIME™ Bristol-Myers Squibb Cefepime HCl Antibiotic Action And Clinical Pharmacology: Cefepime is a semi-synthetic broad spectrum cephalosporin antibiotic intended for i.m. or i.v. administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria. The average elimination half-life of cefepime is approximately 2 hours, and does not vary with respect…