Medrol Veriderm (Methylprednisolone)

MEDROL® VERIDERM® Cream

Pharmacia & Upjohn

Methylprednisolone

Topical Glucocorticoid

Indications And Clinical Uses: Noninfected dermatoses, including allergic dermatoses, pruritus ani and vulvae, atopic and seborrheic dermatitis and contact dermatitis, induced by poison ivy, cosmetics, chemicals or drugs.

Contra-Indications: Tuberculosis of the skin, herpes simplex, vaccinia, varicella and other cutaneous infections for which an effective agent is not available for simultaneous application. Do not use in the eye or in patients sensitive to any of the components.

Precautions: Although untoward effects associated with the use of topical corticosteroids are uncommon and not to be expected from ordinary use, sensitization, irritation and failure of therapeutic response have been noted in rare instances. Application to extensive areas, too frequent application, or application under occlusive dressings may result in systemic absorption with symptoms of adrenal suppression, localized atrophy and striae. If secondary bacterial infection exists or supervenes, concomitant antimicrobial therapy is indicated.

Convulsions have been reported with concurrent use of methylprednisolone and cyclosporine. Since concurrent use of these agents results in a mutal inhibition of metabolism, it is possible that convulsions and other adverse events associated with the individual use of either drug may be more apt to occur.

Pregnancy: The safety of the use of topical steroid preparations during pregnancy has not been fully established. Therefore, steroids should not be used unnecessarily during pregnancy or for prolonged periods of time.

Adverse Reactions: The following adverse skin reactions have been reported rarely with the use of topical steroids: dryness, itching, burning, local irritation, striae, hypopigmentation, atrophy and secondary infection. When occlusive dressings are used, pustules, folliculitis and pyoderma may occur.

Dosage: Careful cleansing of the affected skin should precede the application of a small amount of ointment. Initially, application may be made 1 to 3 times a day. Frequency of application may be reduced after control has been achieved.

Availability And Storage: Each g contains: methylprednisolone acetate 2.5 mg (0.25%) in Veriderm, a skin lipid base. Nonmedicinal ingredients: butyl hydrolytol, butyl hydroxyan, butylparaben, cetyl palmitate, cetyl alcohol, cholesterol, corn oil, glycerin, lexemul ar, methylparaben, mineral oil, oleic acid, oleyl alcohol, perfume oil, polyoxyl 40 stearate, sorbitan monooleate, squalene, stearic acid, stearyl alcohol, tocopherol and water. Tubes of 25 and 50 g.

MEDROL® VERIDERM® Cream Pharmacia & Upjohn Methylprednisolone Topical Glucocorticoid

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