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MINTEZOL® MSD Thiabendazole Anthelmintic Action And Clinical Pharmacology: Thiabendazole is an anthelmintic for the treatment of various nematode infections of man. Thiabendazole provides systemic treatment for cutaneous larva migrans. It causes worms to be eliminated spontaneously from the cutaneous blister or it eases their manual removal. In some instances the devitalized worm is not expelled and encystment with lysis occurs. In some patients, the drug has been useful in the…

MIOCHOL®-E CIBA Vision Acetylcholine Chloride – Electrolytes Miotic Action And Clinical Pharmacology: Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by hydrolysis to acetic acid and choline. Direct application of acetylcholine to the iris will cause rapid miosis of short duration. Topical ocular instillation…

MIGRANAL® Novartis Pharmaceuticals Dihydroergotamine Mesylate Migraine Therapy Action And Clinical Pharmacology: Dihydroergotamine displays agonist activity at the 5-HT1D receptor, which, by reducing 5-HT neuronal function and/or contracting elements of the cranial vasculature and/or suppressing neurogenic inflammation, is believed to underlie its antimigraine efficacy. It also displays affinity for the 5-HT1C receptor and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine displays blocking actions at alpha adrenoreceptors, with a direct stimulating effect…

MIN-OVRAL® 21 MIN-OVRAL® 28 Wyeth-Ayerst Levonorgestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Although the primary mechanism of action is inhibition of ovulation, the effectiveness of Min-Ovral may also result from other mechanisms of action, such as hostility of the cervical mucus to sperm penetration and migration. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or…

MICROLAX® Pharmacia & Upjohn Micro-Enema Indications And Clinical Uses: Rectal constipation; or, as directed by a physician, to facilitate rectoscopic or sigmoidoscopic examination. Adverse Reactions: No severe reactions have been reported. Very occasionally slight cramps or tenesmus may occur. Dosage: Adults and children: the contents of 1 tube (5 mL) administered rectally but a second tube may be needed in severe cases; children under 3 years, insert only half the…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

MIDAMOR® MSD Amiloride HCl Antikaliuretic – Diuretic Action And Clinical Pharmacology: Amiloride is an antikaliuretic drug with mild natriuretic diuretic and antihypertensive activity. The activities may be additive to the effects of thiazides or other saluretic-diuretic agents. The principal use is to conserve potassium in selected patients receiving kaliuretic-diuretic agents. Amiloride interferes with the mechanism involved in the exchange of sodium for potassium in the distal convoluted tubule and collecting…

MICRONOR® Janssen-Ortho Norethindrone Oral Contraceptive Action And Clinical Pharmacology: The mechanism of contraception action of Micronor tablets is multicausal, primarily at the local pelvic level and secondarily at the systemic level. The hormonal effect is mainly progestational. Pelvic effects include changes in the cervical mucus and endometrium. Systemic effects involve mainly the inhibition of secretion of pituitary gonadotropins which in turn prevents follicular maturation and ovulation. Studies by Moghissi, Beck,…

MEXITIL® Boehringer Ingelheim Mexiletine HCl Antiarrhythmic Action And Clinical Pharmacology: Mexiletine is a class 1B antiarrhythmic agent based on the classification system of Vaughan-Williams with local anesthetic properties, similar in structure and activity to lidocaine. Mexiletine blocks the fast sodium channel in cardiac tissues, especially the Purkinje network, without involvement of the autonomic system. Mexiletine reduces the rate of rise and amplitude of the action potential and decreases automaticity (increases…

MICANOL® Canderm Pharma Anthralin Psoriasis Treatment Action And Clinical Pharmacology: Micanol cream provides the action of anthralin in a pharmaceutically elegant base formulated to minimize staining and irritation. With successful treatment, scales will be removed and the lesions will flatten. The lesions will take time to blanch after flattening has occurred. Indications And Clinical Uses: For the treatment of psoriasis. Contra-Indications: Do not use on areas of skin where inflammation…