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OCUCLEAR® Schering Oxymetazoline HCl Topical Decongestant Action And Clinical Pharmacology: Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug’s action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis. Oxymetazoline has a lesser tendency to dilate the pupils than 0.12% phenylephrine. There are no clinical data available on the degree and rate of systemic absorption of oxymetazoline when used topically…

OCUFLOX™ Allergan Ofloxacin Antibacterial Agent Action And Clinical Pharmacology: The primary mechanism of action of ofloxacin appears to be the specific inhibition of DNA gyrase (topoisomerase II). This enzyme is responsible for the negative supercoiling of bacterial DNA and consequently for its topological configuration, governing functions such as RNA transcription, protein synthesis, DNA replication and repair functions. Indications And Clinical Uses: For the treatment of conjunctivitis when caused by susceptible…

OGEN® Pharmacia & Upjohn Estropipate Estrogen Action And Clinical Pharmacology: Estropipate is a natural estrogenic substance prepared from purified crystalline estrone, solubilized as the sulfate and stabilized with piperazine. It is appreciably soluble in water and has almost no odor or taste. The amount of piperazine in estropipate is not sufficient to exert a pharmacological action. Its addition ensures solubility, stability and uniform potency of the estrone sulfate. Estrogens are…

OMNI-TUSS® Rh´ne-Poulenc Rorer Codeine – Chlorpheniramine – Ephedrine – Phenyltoloxamine (Resin Complex) Antitussive – Decongestant – Expectorant Indications And Clinical Uses: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Hypertension, cardiac disease, hyper- thyroidism, prostatic hypertrophy, sensitivity to any of the components, patients receiving MAO inhibitors. Precautions: Before prescribing medication to suppress or modify cough,…

NYTOL™, NYTOL™ Extra Strength Block Drug Diphenhydramine HCl Sleep Aid Action And Clinical Pharmacology: The primary action of diphenhydramine is the antagonism of certain effects of histamine such as broncho-constriction and capillary dilation. The most frequently encountered secondary effects of diphenhydramine are related to CNS depression. The effects vary from slight drowsiness to deep sleep and have been reported to include the inability to concentrate, lassitude, dizziness, muscular weakness and…

NURSOY® Wyeth-Ayerst Soy Protein Isolate Hypoallergenic Infant Formula Indications And Clinical Uses: A nutritionally complete soy-based and milk- and lactose-free formula for common infant feeding problems associated with lactose intolerance or cow’s-milk protein sensitivity or allergy. Symptoms that may require a milk-free formula include diarrhea, vomiting, spitting up, feeding difficulties, gas, bloating, colic, and fussiness. Iron-fortified Nursoy contains vitamin A in the form of beta-carotene and has a fat blend…

NUTRISOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100%…

NUTRISOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard, fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100% of the Canadian…

NOZINAN® Rhône-Poulenc Rorer Methotrimeprazine Neuroleptic Action And Clinical Pharmacology: Methotrimeprazine possesses antipsychotic, tranquilizing, anxiolytic, sedative and analgesic properties and it is also a potent potentiator of anesthetics. Methotrimeprazine possesses strong sedative properties. It potentiates ether and hexobarbital anesthesia as well as morphine analgesia. It also exerts a potent anti-apomorphine effect, a hypothermic action 3 times more potent than that of chlorpromazine and strong antispasmodic and anti-histaminic effects. Methotrimeprazine is capable…

NUMORPHAN® DuPont Pharma Oxymorphone HCl Analgesic Action And Clinical Pharmacology: Oxymorphone is a potent narcotic analgesic. When administered parenterally, 1 mg is approximately equivalent in analgesic activity to 10 mg of morphine sulfate. The onset of action of parenterally injected oxymorphone is rapid and the initial effects are usually perceived within 5 to 10 minutes, with analgesia persisting for approximately 3 to 6 hours. Oxymorphone is conjugated with glucuronic acid…