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OSTAC® Roche Clodronate Disodium Bone Metabolism Regulator Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which act primarily on bone. This tissue specificity is due to the high affinity of bisphosphonates for calcium phosphate crystals. Clodronate forms complexes with the hydroxyapatite of bone, altering the crystalline structure in such a way that dissolution of the crystals is inhibited. The major effect of clodronate is to inhibit osteoclast-mediated…

ORTHOCLONE OKT® 3 Janssen-Ortho Muromonab-CD3 Immunosuppressant Action And Clinical Pharmacology: Muromonab-CD3 sterile solution is a murine monoclonal antibody to the T3 (CD3) antigen of human T cells which functions as an immunosuppressant. It is for i.v. use only. The antibody is a biochemically purified IgG2a immunoglobulin with a heavy chain of approximately 50 000 daltons and a light chain of approximately 25 000 daltons. It is directed to a glycoprotein…

ORTHO® 1/35 ORTHO® 0.5/35 ORTHO® 10/11 ORTHO® 7/7/7 Janssen-Ortho Norethindrone – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action of this product is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or…

ORTHO-NOVUM® 1/50 Janssen-Ortho Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Acts through the mechanism of gonadotropin suppression primarily at the pituitary-ovarian axis with secondary pelvic involvement. Conception Control: The contraceptive efficacy is attributed to suppression of ovulation with a possible contribution from alterations in cervical mucus and in the endometrium. Amenorrhea: Where normal cycling does not occur, as in amenorrhea, the temporary cyclic administration of Ortho-Novum 1/50 Tablets,…

ORO-CLENSE Germiphene Chlorhexidine Gluconate Antigingivitis Oral Rinse Action And Clinical Pharmacology: Chlorhexidine provides antimicrobial activity during oral rinsing which is maintained between rinsings. Microbiologic sampling of plaque has shown a general reduction of both aerobic and anaerobic bacterial counts through 6 months’ clinical use. Rinsing with chlorhexidine inhibits the build up and maturation of plaque by reducing certain microbes regarded as gingival pathogens, thereby reducing gingivitis. Chlorhexidine provides antimicrobial activity…

ORTHO-CEPT® Janssen-Ortho Desogestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action of Ortho-Cept tablets is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. tag_IndicationsIndications Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders. History of/or actual cerebrovascular…

ORTHO® DIENESTROL Janssen-Ortho Dienestrol Vaginitis Therapy Action And Clinical Pharmacology: Dienestrol is a synthetic, nonsteroidal estrogen. The degree of systemic absorption and the mode of action are undetermined. However, one should be aware of the potential for systemic estrogen activity and related risks. Indications And Clinical Uses: The treatment of senile or atrophic vaginitis or other vaginal disturbances associated with hypoestrogenic conditions. Ortho Dienestrol cream is an estrogen product for…

ORAFEN® Technilab Ketoprofen Nonsteroidal Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Pharmacological studies in animals have demonstrated that ketoprofen is an NSAID that possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Ketoprofen, like other nonsteroidal anti-inflammatory analgesics is an inhibitor of prostaglandin synthesis. In vivo studies have demonstrated that ketoprofen is 8 times as potent as indomethacin in inhibiting the synthesis…

OPTIRAY® Mallinckrodt Ioversol Radiopaque Medium Action And Clinical Pharmacology: General: The pharmacokinetics of ioversol in normal subjects conform to an open 2 compartment model with first order elimination (a rapid alpha phase 6.8 minutes, for drug distribution and a slower beta phase 92 minutes, for drug elimination). Based on the blood clearance curves for 12 healthy volunteers (6 receiving 50 mL and 6 receiving 150 mL of Optiray 320), the…

OPTIMINE® Schering Azatadine Maleate Antihistamine Indications And Clinical Uses: The symptomatic relief of respiratory allergic conditions which include acute and chronic allergic rhinitis, pollenosis (hay fever), and vasomotor rhinitis. rhi Also indicated in the symptomatic relief of such allergic dermatological conditions as acute and chronic urticaria, angioneurotic edema, allergic eczema, contact dermatitis, insect bites, pruritus vulvae and ani, pruritus of nonspecific origin, drug and serum reactions, dermographism; for anaphylactic reactions,…