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PROFASI® HP Serono Chorionic Gonadotropin Gonadotropin Action And Clinical Pharmacology: Chorionic gonadotropin, extracted from the urine of pregnant women, is a water-soluble polypeptide hormone produced by the human placenta composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone…

PROGLYCEM® Schering Diazoxide Hyperglycemic Agent Action And Clinical Pharmacology: Diazoxide, a benzothiadiazine derivative, when administered orally produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas and also to an extrapancreatic effect. The hyperglycemic effect begins within an hour and generally lasts no more than 8 hours in the presence of normal renal function. Diazoxide decreases the excretion of sodium…

PROGRAF® Fujisawa Tacrolimus Immunosuppressant Action And Clinical Pharmacology: Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Mechanism of Action: Tacrolimus prolongs the survival of the host and transplanted graft in animal transplant models of liver, kidney, heart, bone marrow, small bowel and pancreas, lung and trachea, skin, cornea and limb. Tacrolimus has been demonstrated to suppress some humoral immunity and, to a greater extent, cell-mediated reactions such as allograft…

PROCTOFOAM™-HC R & C Hydrocortisone Acetate – Pramoxine HCl Anorectal Therapy Action And Clinical Pharmacology: Proctofoam-HC combines the anti-inflammatory action of hydrocortisone with the surface anesthetic effect of pramoxine HCl. tag_IndicationsIndications Indications And Clinical Uses: The temporary relief of anorectal inflammation, pruritus, pain and swelling associated with hemorrhoids, proctitis, cryptitis, fissures, postoperative pain and pruritus ani. Contra-Indications: The presence of active infection, abscess, extensive fistulas or sinus tracts, tuberculosis, varicella,…

PROCTOSEDYL® Hoechst Marion Roussel Hydrocortisone – Framycetin Sulfate – Cinchocaine HCl – Esculin Anorectal Therapy Indications And Clinical Uses: The reduction of swelling, pain and inflammation of hemorrhoids and other rectal lesions. The management of acute and chronic nonspecific proctitis, acute internal hemorrhoids, cryptitis, fissures and incomplete fistulas, internal and external pruritus ani. May be used in pre- and postoperative hemorrhoidectomy and repair of fissures. Contra-Indications: Hydrocortisone must not be…

PROCYTOX® Carter Horner Cyclophosphamide Antineoplastic Action And Clinical Pharmacology: Although it is classified generally as an alkylating agent, cyclophosphamide itself is not an alkylating agent. It appears to be inactive in vitro when tested on cultures of human leukocytes or carcinomatous cells of human origin. It appears active metabolites of the drug exhibit the alkylating action. carc Cyclophosphamide’s metabolism is initiated by the mixed function oxidase enzymes of the liver…

PRODIEM® PLUS Novartis Consumer Health Psyllium – Senna Bulk Forming Laxative – Mild Stimulant Action And Clinical Pharmacology: Prodiem Plus is a unique combination of a bulk forming fibre and a mild stimulant. It is a gentle method for the relief of acute and obstinate constipation without harsh chemical laxatives and is often effective in 12 to 24 hours Psyllium is a high fibre bulk forming laxative. It absorbs water…

OXSORALEN™ ICN Methoxsalen Melanin Repigmentation – Photochemotherapy of Atopic Dermatitis and Psoriasis Indications And Clinical Uses: Repigmentation of vitiliginous lesions, to protect against solar sensitivity. Oral route is preferred if extensive repigmentation is desired, since topical application can only be applied to a small area at a time. For treatment of psoriasis and atopic dermatitis in combination with high intensity UVA light. Contra-Indications: Hepatic insufficiency. Diseases associated with photosensitivity, such…

OXYCONTIN® Purdue Frederick Oxycodone HCl Opioid Analgesic Action And Clinical Pharmacology: Oxycodone is a semisynthetic opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, oxycodone produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

OXYTOCIN INJECTION, USP Abbott Oxytocic Action And Clinical Pharmacology: Oxytocin synthetic, acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the…