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PROCAN™ SR Parke-Davis Procainamide HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Procainamide depresses the excitability of cardiac muscle to electrical stimulation, and slows conduction in the atrium, the bundle of His, and the ventricle. The refractory period of the atrium is considerably more prolonged than that of the ventricle. With therapeutic plasma levels of the drug, contractility of the heart is usually not affected nor is cardiac output decreased to…

OXIZOLE® Stiefel Oxiconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Oxiconazole nitrate is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini,…

OXSORALEN-ULTRA™ ICN Methoxsalen Melanin Repigmentation – Tolerance Increase to Solar Exposure – Photochemotherapy of Atopic Dermatitis and Psoriasis Indications And Clinical Uses: Repigmentation of idiopathic vitiligo; increasing tolerance to sunlight. Treatment of psoriasis and atopic dermatitis in combination with high intensity UVA light (photochemotherapy). Contra-Indications: Hepatic insufficiency and in those diseases associated with photosensitivity; such as porphyria, acute lupus erythematosus, hydroa and polymorphic light eruptions. In leukoderma of infectious origin…

OTRIVIN® Novartis Consumer Health Xylometazoline HCl Nasal Decongestant Indications And Clinical Uses: Nasal congestion in colds, rhinitis, sinusitis; also for headache, tubal block and serous otitis media associated with nasal congestion. Xylometazoline facilitates rhinoscopy and is a useful pre- and postoperative adjunct. Contra-Indications: Narrow-angle glaucoma. Concurrent therapy with MAO inhibitors. Hypersensitivity to any component. Sensitivity to even small doses of adrenergic substances as manifested by sleeplessness, dizziness, lightheadedness, weakness, tremulousness,…

OSTOFORTE® Frosst Vitamin D2 (Ergocalciferol) Vitamin Indications And Clinical Uses: Treatment of refractory rickets (vitamin D-resistant rickets), familial phosphatemia and hypoparathyroidism. Contra-Indications: Hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, hypervitaminosis D, decreased renal function. Precautions: Hypersensitivity to vitamin D may be one etiological factor in infants with idiopathic hypercalcemia. In these cases, vitamin D must be severely restricted. Pregnancy: Safety in excess of 400 IU…

OVOL® Preparations Carter Horner Simethicone Antiflatulent Indications And Clinical Uses: Specifically for symptomatic treatment of gastrointestinal discomfort due to entrapped gas. Relief of infant colic. Symptoms And Treatment Of Overdose: Symptoms and Treatment: Treatment symptomatic. Dosage And Administration: Drops: Infants, 0.25 to 0.50 mL with or after each meal. May be added to formula or given directly from dropper. Maximum: 6 mL/24 hours. Tablets: Adults: 40 mg (2 tablets, 4…

OXEZE® TURBUHALER® Astra Formoterol Fumarate Dihydrate Bronchodilator Action And Clinical Pharmacology: Pharmacodynamics: Formoterol produces bronchodilation by stimulation of the b2-adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of smooth muscle fibres. Following inhalation of formoterol, a marked improvement in pulmonary function is observed within 1 to 3 minutes and lasts for a mean duration of 12 hours after a single dose. Pharmacokinetics: Absorption: Inhaled formoterol is rapidly absorbed. Peak…

ORUDIS® ORUDIS® E ORUDIS® SR Rhône-Poulenc Rorer Ketoprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Animal pharmacological studies have shown that ketoprofen is a NSAID that possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Its therapeutic effectiveness has been demonstrated by a reduction in joint swelling, pain and duration of morning stiffness, and by increased grip strength and an improvement in…

ORUVAIL® May & Baker Pharma Ketoprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Animal pharmacological studies have shown that ketoprofen possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Its therapeutic effectiveness has been demonstrated by a reduction in joint swelling, pain and duration of morning stiffness, and by increased grip strength and an improvement in functional capacity. Clinical trials in patients…

OSMOVIST® Berlex Canada Iotrolan Dimeric Nonionic Radiographic Contrast Medium for Myelography Action And Clinical Pharmacology: Iotrolan is a dimeric, nonionic, hexaiodinated radiocontrast medium. The contrast-giving substance, iotrolan, is a dimer of triiodinated isophthalic acid derivatives, in which the firmly bound iodine absorbs the x-rays. Solutions of iotrolan are isotonic to plasma and cerebrospinal fluid at radiologically useful iodine levels. After intrathecal administration, iotrolan is absorbed from cerebrospinal fluid (CSF) into…